DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and Slc6a11

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_766478.1	Gene:	Slc6a11 / 243616	MGIID:	95630	Length:	627	Species:	Mus musculus

Alignment Length:	546	Identity:	227/546 - (41%)
Similarity:	342/546 - (62%)	Gaps:	13/546 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGR 403
            ||.||::|||:..|..:||||||||||:|||:|||.||:||.:....|.||:.|:|.::||:|..
Mouse    47 HWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSE 111

  Fly   404 GPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCW 468
            |.|....::||||:|.|.|:.|:...::.||.:|:.::|:|....|.||:||..|.:.|||..|.
Mouse   112 GGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCV 176

  Fly   469 VPQRKGINAS-----APDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATW 528
            ..|:  :|.|     :...:.:|..||:|.:||.||.|:|:.|.:||||..||:.||.:.||..|
Mouse   177 EFQK--LNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIW 239

  Fly   529 KSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNS 593
            |..||:.||.|.|||||:::::||::|.|||.||:||::|:..|..|.|.:..||::|.:|.|.|
Mouse   240 KGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFS 304

  Fly   594 LGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDG 658
            ..|..|.:.:..|||.||||..||.:.:..:|..||.:.|...||.||.:|.||...:.:|...|
Mouse   305 YAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESG 369

  Fly   659 PGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY-HE 722
            ||:.|:.||:|:..||.:.|||.:||.||:.|||:|||..||.:||::.|.:|:..:|  || .|
Mouse   370 PGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRR--GYRRE 432

  Fly   723 IVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQ 786
            :::|.:.:||...|:..:.:||:|.|||.|.|||| :.::|:|..:.:.|.|.||:.|...|::.
Mouse   433 LLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIED 497

  Fly   787 MTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIP 851
            |.|..|...::.||.|:.|.:...|::..|:.| :|..:|..||||.|.|||||:.|..|::|||
Mouse   498 MIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKY-KPLKYNNVYTYPAWGYGIGWLMALSSMLCIP 561

  Fly   852 GYAVINFLRSSGDTFWERIRNTLRPN 877
            .:..|...::.| |..|:::....|:
Mouse   562 LWIFIKLWKTEG-TLPEKLQKLTVPS 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	226/543 (42%)
Slc6a11	NP_766478.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_766478.1	SLC6sbd_GAT3	44..585	CDD:212077	226/543 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820