Protein Alignment ine and Slc6a1

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_848818.1
• Gene: Slc6a1 / 232333
• MGIID: 95627
• Length: 599
• Species: Mus musculus
• Alignment Length: 598
• Identity: 231/598 - (38%)
• Similarity: 364/598 - (60%)
• Gaps: 30/598 - (5%)

  Fly   285 STDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLA 349
            :||..|:...::.|..:|          .|:..|...:.:....:.|...|.:..|..:..|:::
Mouse     2 ATDNSKVADGQISTEVSE----------APVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMS 56

  Fly   350 CIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALG--QL 412
            |:||::||||||||||:|.|:|||.||:||.:.|....:||..:|.|:||||.   ||.||  :|
Mouse    57 CVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTS---IGGLGVWKL 118

  Fly   413 CPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINA 477
            .|:|||.|||:.|:||.::.||.|||.::|||.:.||.|.:||..|:|.|||..|:      .|.
Mouse   119 APMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCF------SNY 177

  Fly   478 SAPDTSRTPSE--EFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYF 540
            |..:|:...|.  ||:|..:.|::.||:.||.:||.|...|..||::|||..||.:..:.||.||
Mouse   178 SLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYF 242

  Fly   541 TATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFA 605
            :||:|::::|||..|.|||.||.||:.|:..|.:.:|.::.||::||:|.|.|.|:..||:|:..
Mouse   243 SATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALG 307

  Fly   606 SYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAM 670
            |||.::||:.||::.|..:|..||:..|...||.:|.:|.....::.||...|||:.|:.||:|:
Mouse   308 SYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAV 372

  Fly   671 AKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLF 735
            .::|.:.|||::||.|||.||::|||..||..:|::.|.:||.::..   .|:.:..||::|.|.
Mouse   373 TQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNR---RELFIAAVCIVSYLI 434

  Fly   736 GMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSC 799
            |:.||.|||||.|:|.|:|:|| ::::||.|.:.::|:||||..|...|:::|.|..|..:.:.|
Mouse   435 GLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLC 499

  Fly   800 WLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGD 864
            |....|.::..:::.|.:.....|.  |.|.:|.|..|:||:.|..|::.||||....||...|
Mouse   500 WSFFTPIIVAGVFLFSAVQMTPLTM--GSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG- 561

  Fly   865 TFWERIRNTLRPN 877
            :..:|::..::|:
Mouse   562 SLKQRLQVMIQPS 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	221/543 (41%)
Slc6a1	NP_848818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/30 (20%)
		SLC6sbd_GAT1	2..599	CDD:212075	231/598 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820