DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and Slc6a17

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001280618.1	Gene:	Slc6a17 / 229706	MGIID:	2442535	Length:	727	Species:	Mus musculus

Alignment Length:	708	Identity:	212/708 - (29%)
Similarity:	341/708 - (48%)	Gaps:	126/708 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 DMVNPQTPPPLGVDDDDSYLDMSDET-AQLKPRQQH--------WANKMQFVLACIGYSVGLGNV 360
            |::..:.|    ||...|.|:::.|| .:.|..::.        |.:|:|::||.||:||||||:
Mouse    23 DLLALEEP----VDYKQSVLNVAGETGGKQKVAEEELDTEDRPAWNSKLQYILAQIGFSVGLGNI 83

  Fly   361 WRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVV 425
            |||||:|.|:|||.:||||.::|.|..|||.|:||:|||...||.||....:||...|.|.:|.:
Mouse    84 WRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCI 148

  Fly   426 VSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEF 490
            |...:..||:||||:|::|||.||:..:||.:|.         |.:...:....|:..::.:..:
Mouse   149 VCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSECP---------VIRNGTVAVVEPECEKSSATTY 204

  Fly   491 F-ENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMV 554
            | ..:.|.||..:...|.:.|::..||:.||.:|..|..|.|:||.||.||::.||:|::...:|
Mouse   205 FWYREALDISNSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLV 269

  Fly   555 RAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTV 619
            |.:.|.||.:|:...|.||..::.:..||..||:|.|.:||:.||.:|:|:||||.:||...|..
Mouse   270 RGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAA 334

  Fly   620 AVSAVNMITSLLVGIFAFSTLG---NLALEQ-------------NTNV--RDVIG---------- 656
            .||.:|..||:|..:..|:.||   |:..|:             |:||  ||:|.
Mouse   335 LVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTT 399

  Fly   657 ------------------------------------DGPGMIFVVYPQAMAKMPYAQLWAVMFFF 685
                                                .|.|:.|:.:.:||...|.:..|:||||.
Mouse   400 KDYSEMYSVIMTVKEKQFPALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFL 464

  Fly   686 MLLCLGLNSQFAIVEVVVTSIQDGF--PRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYF 748
            ||:.|||.|....:..:.|.|.|.|  |:         |:..:..||.:...|:..:.:.|.|:.
Mouse   465 MLINLGLGSMIGTMAGITTPIIDTFKVPK---------EMFTVGCCVFAFFVGLLFVQRSGNYFV 520

  Fly   749 QLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWV 813
            .:.|.|:|::.:..:...:.||:||.|||.:..:.:.:|.|..|..:....|..:.|..:..:..
Mouse   521 TMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFQPYRFYFYMWKFVSPLCMAVLTT 585

  Fly   814 LSLI--NYHEPTYH-------NGRYTY-PDWAYGIGWMFASFSLICIPGYAVINFLR-----SSG 863
            .|:|  ....|.|.       ..||.| |:||..:.....:.:.:.||   |:..||     |.|
Mouse   586 ASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIP---VVFILRHFHLLSDG 647

  Fly   864 DTFWERIRNTLRPNIYECKICGE-HHCEHDYPEQEQFMLAQEMATVYKPTNPHLLNLG 920
            .       |||..:..:.::..: .:.|.:  ::.:|:|::..:....|...|...||
Mouse   648 S-------NTLSVSYKKGRMMKDISNLEEN--DETRFILSKVPSEAPSPMPTHRSYLG 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	196/628 (31%)
Slc6a17	NP_001280618.1	SLC6sbd_NTT4	60..648	CDD:271403	192/608 (32%)
Slc6a17	NP_001280618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727		4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810