Protein Alignment ine and dat-1

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_499043.1
• Gene: dat-1 / 176304
• WormBaseID: WBGene00000934
• Length: 615
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 211/589 - (35%)
• Similarity: 331/589 - (56%)
• Gaps: 53/589 - (8%)

  Fly   324 LDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSI 388
            :|....|....|.::.|:.|:.|:|:.:|::|.|||:|||||:|:|:||||||:||.|::.:..:
 Worm    27 IDGPVNTEPKDPAREQWSGKLDFLLSVVGFAVDLGNIWRFPYLCFKNGGGVFLIPYSIMVLLTGV 91

  Fly   389 PLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEM 453
            ||.:|||.:|||..:|.|...|::||||||.|...::.:|.:..:|:||:.:.::|.:|||...:
 Worm    92 PLFYMELCLGQYYRKGAITTWGRICPLFKGIGYCVILTAFYVDFFYNVILAWGLHYLYTSFSFNL 156

  Fly   454 PWIDCNNRWNTPDCWVP--------QRKGINASAPDTSRTPSEEFFENKVLQISGGLEYP----- 505
            ||..|||.:|:|.|:.|        ..:..|.|......:.:||:|....|    ||...
 Worm   157 PWASCNNSYNSPACYEPHWSEDGTAMCRSANQSVSAEKISAAEEYFYKGFL----GLHEANAPNS 217

  Fly   506 ---------GMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDG 561
                     |.:||::...|...:|:.||:.||.|.:|.||.:|||.||:|::.||.:|.|||.|
 Worm   218 HVIRSVTDLGNVRWDIALSLFVVYLICYFSMWKGIHTSGKVVWFTALFPYVVLGILFIRGVTLPG 282

  Fly   562 AAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNM 626
            ...|:.::.||.:..||..:||.:||:|.|.|||..||.:::::|||.::||:..|.:..|.:|.
 Worm   283 WQNGIEYYLRPNFEMLKRPSVWQDAATQVFFSLGPGFGVLMAYSSYNDFHNNVYVDALFTSFINC 347

  Fly   627 ITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLG 691
            .||.|.|...||.||.::.:....:..|..:|||::|||||:|::.||||..|:|:||.||:.||
 Worm   348 ATSFLSGFVIFSVLGYMSCKSGKPIEAVAQEGPGLVFVVYPEALSTMPYAPFWSVLFFLMLMTLG 412

  Fly   692 LNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLF------GMPNIIQGGIYYFQL 750
            |:|.|...|.::|.:.|.|| .:|::   .|:.|      .|||      |:....:|||...:.
 Worm   413 LDSSFGGSEAIITGLSDEFP-ILKKN---REVFV------GCLFAFYMVIGIAMCTEGGILIMEW 467

  Fly   751 MDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLS 815
            :..|..:..::...||:.:.||:.||..:...:||:|.|..|..|.:.||....|.:|.::...:
 Worm   468 LIIYGTTWGLLIAVFCEAMVIAYIYGLRQFVHDVKEMMGFRPGNYWKFCWSCAAPFILLSMITSN 532

  Fly   816 LINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTF---WERIRNTL--- 874
            .|||...||.:  ||||..|..||.:||......||...:..|:.:.|:|.   |:|:  |:
 Worm   533 FINYQALTYQD--YTYPTAANVIGIIFALSGASFIPLVGIYKFVNARGNTISEKWQRV--TMPYR 593

  Fly   875 -RPN 877
             |||
 Worm   594 KRPN 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	205/573 (36%)
dat-1	NP_499043.1	SLC6sbd_SERT-like_u1	40..591	CDD:271405	205/568 (36%)