DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and snf-5

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_496735.1	Gene:	snf-5 / 174923	WormBaseID:	WBGene00004904	Length:	728	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	203/733 - (27%)
Similarity:	328/733 - (44%)	Gaps:	129/733 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 MATSG-------LQAP-----NPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLAS-IGIGS 285
            ||.||       .|||     :|....|| .:|..|        ||:.|..:..:|..| |....
Worm     1 MADSGSNEEAMKRQAPSVKFDSPSKPDPQ-QVSQQS--------NQLSSQKSIQQSTQSKIDPSR 56

  Fly   286 TDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLAC 350
            .|.:...:    ||.....|     |||    ::::.             ::..:.|..:|||..
Worm    57 IDTKNTTV----TTTRPTLD-----TPP----EEEEE-------------KRDGFGNSFEFVLTS 95

  Fly   351 IGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPL 415
            :|.:|||||:||||...|.:||..||:||....|:..:|.::.|...|||.|:.|.....::.|:
Worm    96 LGLAVGLGNIWRFPTRAYNNGGSAFLIPYLTCAFLFGLPAVYFEFLTGQYQGKSPPVIFRRVRPI 160

  Fly   416 FKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMP-WIDCNNRWNT-PDC----------- 467
            .:|.|...|.|:.|::.||.||:.:...|.....:.... |..|||.||. ..|
Worm   161 LEGVGWMGVFVAALVAIYYIVIVSWISIYMINICRGHFALWSHCNNDWNNGTSCITMADQYLCKN 225

  Fly   468 ----------W-----VPQR----KGI--NASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWE 511
                      |     :|.:    .|.  :|:..|.| |.:|::|...::|.|.|:...|...|.
Worm   226 HTKVMANSTLWNSSLPIPDKMVYFNGACQDANGTDVS-TATEQYFMTYIVQPSSGMLDFGGFNWP 289

  Fly   512 LFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFF-RPKWS 575
            :||.:...||:......|..|...|:.|.:...|:||:::|.:..|..||:..||..:| .|.::
Worm   290 VFAAMSVCWLLTGLGILKGAKIMGKISYVSVLVPYVLVVVLFINGVFQDGSGVGLEMYFGTPNYT 354

  Fly   576 ELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTL 640
            :|...:.|..|..|...||.:..|.:||.:||:...|||.||.:.|...:...||:.|...|:||
Worm   355 KLYEQDTWTEALKQLCFSLSVGHGGLISLSSYSPKRNNIFRDALIVIIGDTTMSLVGGGAVFATL 419

  Fly   641 GNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTS 705
            |.||.....:|:||:..|..:.|||||:||.:||...||..:||.||..||.:::.|:|:|..:.
Worm   420 GYLAKATGQDVKDVVKSGLSLAFVVYPEAMTRMPVPWLWCFIFFLMLFLLGASTEIALVDVFCSC 484

  Fly   706 IQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIA 770
            |.|.:||:..|..    |||:..|.:....|:....:.|.|:|::.|.|||..:.:....|:::.
Worm   485 IYDQYPRFRNRKW----IVVIAWCSVLYCIGLVFSTRAGYYWFEMFDEYAAGFSSVCTVVCELLV 545

  Fly   771 IAWFYGTGRLSKNVKQMTGK----------APSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYH 825
            :.:.||...:..::.::.|.          |.|:|..:.|:|:.|.:...:..||.:..:.   :
Worm   546 MMYIYGFRNVRDDITEVVGHARNKFTGAIGAHSWYFTANWMVISPSIALILVGLSFVREYP---Y 607

  Fly   826 NGRY-TYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHC 889
            .||: .||......||..:...:|.:|.:.::||:|                    |:..|
Worm   608 MGRHDIYPAVFDIFGWFLSFLPVIIVPIFMLLNFIR--------------------CRNRG---- 648

  Fly   890 EHDYPEQEQFMLAQEMAT 907
             |.|  :..|||.::.|:
Worm   649 -HSY--RTLFMLQKQHAS 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	170/584 (29%)
snf-5	NP_496735.1	SLC6sbd	83..601	CDD:271359	158/522 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810