Protein Alignment ine and mod-5

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_491095.3
• Gene: mod-5 / 171879
• WormBaseID: WBGene00003387
• Length: 671
• Species: Caenorhabditis elegans
• Alignment Length: 695
• Identity: 231/695 - (33%)
• Similarity: 363/695 - (52%)
• Gaps: 83/695 - (11%)

  Fly   189 SVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPNPLYMQPQASL 253
            |.|.|.||.....|:....|......|.|:| ||.:...|.  ::::||....||    :|.|:|
 Worm    21 SGAASMLSAPESRRVSRSMSVKAPTASEYMP-LSVADKPLT--LTVSTSHSIDPN----EPIAAL 78

  Fly   254 SGSSYHFHELAGNQIYSDVTSVRSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVD 318
            .|                :|..:          :||...:||..:...:
 Worm    79 GG----------------LTPTK----------EGRVAALRRRSSMVRD---------------- 101

  Fly   319 DDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIIL 383
                                .||.||:|:||.:||:|.|||:||||.:|||.|||.||:||.|:|
 Worm   102 --------------------KWATKMEFLLAVVGYAVDLGNIWRFPSVCYKHGGGAFLIPYFIML 146

  Fly   384 FICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTS 448
            .|..:|:.:|||.:||:...|.:....::||||:|.|.....:...::.:|:.||..::|:...|
 Worm   147 MIGGLPMFYMELVLGQFHRSGCVSIWRKVCPLFRGIGYGICCICTFIAIFYNAIIAQAVYFAIVS 211

  Fly   449 ----FKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQI--SGGLEYPGM 507
                :.:|:||..|.|.||||.|.......|:.:....: |||||::..|||::  |.|.:..|.
 Worm   212 LSKIWDSEVPWASCGNPWNTPRCSDDLNVTISRNGTPLT-TPSEEYYLYKVLEVQKSTGFDDLGG 275

  Fly   508 MRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRP 572
            ::..:..||:..::|||||.||..:||.|:.:.|||.|::::.||::|.:.|.||..||.::..|
 Worm   276 VKTSMAVCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYIILSILLIRGLLLPGAKNGLYYYVTP 340

  Fly   573 KWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAF 637
            .:.:||:..||..||:|.|.|||..||.:::.:|||.:|||..||.|..|.:|..||...|...|
 Worm   341 DFEKLKDPAVWSAAATQIFFSLGPGFGVLLALSSYNDFNNNCYRDAVTTSIINCATSFFSGCVVF 405

  Fly   638 STLGNLALEQNTNVRDVIGD-GPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEV 701
            ||||.::|..|..:.:|:|: ...:||:|||||:|.|.|:..|:.:||.||:.||::|.||.:|.
 Worm   406 STLGYMSLLTNKPINEVVGEHDASLIFIVYPQALATMDYSCFWSFIFFVMLITLGIDSTFAGIEA 470

  Fly   702 VVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFC 766
            .:|...|. .|::.::   .:..||.:|:|......|.|..||.:....:|.|..|::::|:..|
 Worm   471 FITGFCDE-SRFLSKN---RKWFVLVICIIYYFLSFPAISYGGQFVIPFLDEYGVSLSVLFIVTC 531

  Fly   767 QMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTY 831
            :|||:.||||..:.||:::.|.|..|..|.|.|| ...|..:..|:::::.|..........||:
 Worm   532 EMIAVCWFYGVDQFSKDIRAMLGFYPGIYWRVCW-TCSPVFISVIFIMTVYNSSFKPIQMASYTF 595

  Fly   832 PDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP 876
            |.|:..:||.....|::.||.:|:|..|..:| |.:||.|..:.|
 Worm   596 PWWSVILGWFLRLLSVLAIPVFAIIYLLSGTG-TLYERFRWAITP 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	204/545 (37%)
mod-5	NP_491095.3	SLC6sbd_SERT-like	100..639	CDD:271388	204/581 (35%)