DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and Slc6a5

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_976079.1	Gene:	Slc6a5 / 171148	RGDID:	621824	Length:	799	Species:	Rattus norvegicus

Alignment Length:	905	Identity:	289/905 - (31%)
Similarity:	442/905 - (48%)	Gaps:	177/905 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 PFRQTSSTTSLAAMAAALHKQSPLRHTSVRTRPSSEVLQPGQVLANQP---TAAVSTSTVTFTID 146
            |.......|::.......|:.||   .:.||.|..::.......|.||   ..:.||...||
  Rat     6 PKEMNKPPTNILEATVPGHRDSP---RAPRTSPEQDLPAAAPAAAVQPPRVPRSASTGAQTF--- 64

  Fly   147 DCNEEGDAIPAAASVPAPVTMPAISPTPATLTCTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMR 211
               :..||....|..|. |....:|...|..|          |.|:..||        ..||:..
  Rat    65 ---QSADARACEAQRPG-VGFCKLSSPQAQAT----------SAALRDLS--------EGHSAQA 107

  Fly   212 SVVSGYLPGLSDSSGNLVGGVSMATSGLQAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVR 276
            :..||       ::|                                     |||.::..:.::|
  Rat   108 NPPSG-------AAG-------------------------------------AGNALHCKIPALR 128

  Fly   277 SLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPP-----------PLGVDDDDSYLDMSDET 330
                   |..:...:.:.:.....|        .|||           .||.|...|.|..|..|
  Rat   129 -------GPEEDENVSVAKGTLEHN--------NTPPVGWVNMSQSTVVLGTDGIASVLPGSVAT 178

  Fly   331 AQLKPRQQ--------HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICS 387
            ..:...:|        :|::|:.|:|:.:||:|||||||||||:.:::|||.||:||.::|.:..
  Rat   179 TTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG 243

  Fly   388 IPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTE 452
            :|:.|:|:|:||:..:||: ::.:..|..:|.|:|.:::|.|::.||:|||.|:::|.|.||.:.
  Rat   244 LPIFFLEVSLGQFASQGPV-SVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSV 307

  Fly   453 MPWIDCNNRWNTPDC-----------------------------WVPQRKGIN--ASAPDTSRTP 486
            :||..|||.||||:|                             ..|....:|  :.|..|..:.
  Rat   308 LPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSG 372

  Fly   487 SEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIII 551
            |||:|:..||:||.|:||||.:||.|..||..||::||.:..|.||:|.||.|||||||:|:::|
  Rat   373 SEEYFKYFVLKISAGIEYPGEIRWPLPFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVI 437

  Fly   552 LMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILR 616
            |::|.|||.||..|:.:|..|||.:|.:|.||.:||:|.|.||...:|.:|:.:||||::||..|
  Rat   438 LLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYR 502

  Fly   617 DTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAV 681
            ||:.|:..|..||:..|...||.:|.:|.|:..|:.:|...|||:.|||||:|:.::|.:..||:
  Rat   503 DTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAI 567

  Fly   682 MFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIY 746
            :||.|||.|||::.||.:|.:||||.|.||::::.|   ..:..|..|:...:.|.|.|.|||||
  Rat   568 IFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTH---KPVFTLGCCICFFIMGFPMITQGGIY 629

  Fly   747 YFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAI 811
            .|||:|.||||..::.:|..:::.|::.||..|..::::.|.|..|:.:.:.||..:.|.:|..|
  Rat   630 MFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFI 694

  Fly   812 WVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP 876
            ...|...:...||  |.|.||:|:..:||:..:.|:|.||...||....:.| .|.||::....|
  Rat   695 LCFSFYQWEPMTY--GSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPG-RFIERLKLVCSP 756

  Fly   877 NIYECKICGEHHCEHDYPEQEQFMLAQEMATVYKPTNPHL-------------LNLGQKC 923
            .                |:...| |||.....||.....|             |.||.:|
  Rat   757 Q----------------PDWGPF-LAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	228/577 (40%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		13/60 (22%)
Slc6a5	NP_976079.1	SLC6sbd_GlyT2	193..789	CDD:271389	236/619 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820