DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and Slc6a4

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_034614.2	Gene:	Slc6a4 / 15567	MGIID:	96285	Length:	630	Species:	Mus musculus

Alignment Length:	561	Identity:	219/561 - (39%)
Similarity:	343/561 - (61%)	Gaps:	26/561 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 QQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYT 401
            ::.|..||.|:|:.|||:|.|||:|||||:||::|||.||:||.|:.....|||.:|||::|||.
Mouse    79 RETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYH 143

  Fly   402 GRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPD 466
            ..|.|....::||:|||.|.|..:::|.:::||:.||.:::||..:||..::||..|.|.|||.:
Mouse   144 RNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGN 208

  Fly   467 CWVPQRKGINASAPDT------SRTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMV 523
            |       .|..|.|.      |.:|:|||:...||||  |.||:..|.:.|:|..|::..:.::
Mouse   209 C-------TNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTII 266

  Fly   524 YFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAAS 588
            ||:.||.:|:|.||.:.|||||::::.:|:||..||.||..|:.|:.:|.|.:|....||::||:
Mouse   267 YFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAA 331

  Fly   589 QNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRD 653
            |.|.|||..||.:::||||||:|||..:|.:..|.||.:||.:.|...|:.||.:|..:|.:|.:
Mouse   332 QIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSE 396

  Fly   654 VIGD-GPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPR-WIKR 716
            |..| ||.::|:.|.:|:|.||.:..:|::||.||:.|||:|.||.:|.|:|::.|.||. |.||
Mouse   397 VAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKR 461

  Fly   717 HLGYHEIVVLFVCVISCLFG-MPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780
                .|..||.| ||:|:.| :..:..||.|...|::.||....::.:|..:.:.::||||..:.
Mouse   462 ----REWFVLIV-VITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQF 521

  Fly   781 SKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASF 845
            ..:||:|.|.:|.::.|.||:.:.|  ||.::::.......|.....:|.||.|:..:|:...:.
Mouse   522 CSDVKEMLGFSPGWFWRICWVAISP--LFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTS 584

  Fly   846 SLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGE 886
            |:||||.|.:...:.:.| |..|||..::.|.......||:
Mouse   585 SVICIPIYIIYRLISTPG-TLKERIIKSITPETPTEIPCGD 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	216/549 (39%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		5HT_transport_N	24..64	CDD:281488
		SLC6sbd_SERT	79..615	CDD:271399	216/550 (39%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820