DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and Slc6a9

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001342104.1	Gene:	Slc6a9 / 14664	MGIID:	95760	Length:	652	Species:	Mus musculus

Alignment Length:	561	Identity:	233/561 - (41%)
Similarity:	342/561 - (60%)	Gaps:	33/561 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGR 403
            :|.|:::|||..:||:|||||||||||:||::|||.|:.||.|:|..|.|||.|||||.||:..:
Mouse    48 NWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQ 112

  Fly   404 GPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCW 468
            |.:| :.::.|:|||.|...:|||..:..||:|:|..:.||||:|....:||..|||.||||||
Mouse   113 GCLG-VWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDC- 175

  Fly   469 VPQRKGI-------NASAP-------------DTSRT-PSEEFFENKVLQISGGLEYPGMMRWEL 512
                .|:       |.|.|             ...|| ||||::...||::|..:...|.:|..|
Mouse   176 ----AGVLDASNLTNGSRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPL 236

  Fly   513 FACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSEL 577
            ..||..:|::|:....:.:|||.||.|||||||:|::.||.||.|||:||..|:.::..|:|.::
Mouse   237 LGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKI 301

  Fly   578 KNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGN 642
            ..|.||.:||||.|.|||..:|.:|:.|||||::||..||:|.:|..|..||:..|...||.||.
Mouse   302 LEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 366

  Fly   643 LALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQ 707
            :|.....:|..|...|||:.||.||:|:..:|.:.||:::|||||:.|||.:||.::|.:||:|.
Mouse   367 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIV 431

  Fly   708 DGF-PRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAI 771
            |.. ..||.:...|   |.|.|.|...|.|:|...|.|||:..|||:||||.:::.::....::|
Mouse   432 DEVGNEWILQKKTY---VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSI 493

  Fly   772 AWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAY 836
            .:.||.....::::.|.|..|..:.:.||..:.|.::|.|.:.::|.|...||::  |.||.||.
Mouse   494 MYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNH--YQYPGWAV 556

  Fly   837 GIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPN 877
            .||::.|..|:||||.||:....|:.|||..:|::|..:|:
Mouse   557 AIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPS 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	232/558 (42%)
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	233/561 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820