Protein Alignment ine and Slc6a3

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 581
• Identity: 231/581 - (39%)
• Similarity: 360/581 - (61%)
• Gaps: 41/581 - (7%)

  Fly   306 MVN-PQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYK 369
            ::| ||||                  .:::.|:. |:.|:.|:|:.||::|.|.|||||||:|||
Mouse    47 LINPPQTP------------------VEVQERET-WSKKIDFLLSVIGFAVDLANVWRFPYLCYK 92

  Fly   370 SGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYY 434
            :|||.|||||.:.:.|..:||.:|||::||:...|..| :.::||:.||.|...:::||.:..:|
Mouse    93 NGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAG-VWKICPVLKGVGFTVILISFYVGFFY 156

  Fly   435 SVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRK------GINASAPDT-SRTPSEEFFE 492
            :|||.::::|||:||..::|||.|||.||:|:|......      |:|    || ..||:.|:||
Mouse   157 NVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLN----DTFGTTPAAEYFE 217

  Fly   493 NKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVR 555
            ..||.:  |.|::..|..||:|.|||:...:::||:.||.:|:|.||.:.|||.|:|::..|::|
Mouse   218 RGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLR 282

  Fly   556 AVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVA 620
            .|||.||.:|:|.:....:..|..|:|||:||:|...|||:.||.:|:|:||||:.||..||.:.
Mouse   283 GVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAII 347

  Fly   621 VSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFF 685
            .:::|.:||...|...||.||.:|.:.|..:|||..||||:||::||:|:|.:|.:..||.:||.
Mouse   348 TTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFL 412

  Fly   686 MLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQL 750
            |||.||::|....:|.|:|.:.|.| :.:.||   .|:..|.:.:.:.|..:..:..||||.|.|
Mouse   413 MLLTLGIDSAMGGMESVITGLVDEF-QLLHRH---RELFTLGIVLATFLLSLFCVTNGGIYVFTL 473

  Fly   751 MDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLS 815
            :||:||..:|:|....:.|.:|||||..:.|.::|||||:.|:.|.|.||.::.||.|..:.|:|
Mouse   474 LDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVS 538

  Fly   816 LINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP 876
            ::.:..|  |.|.|.:||||..:||:.|:.|:..:|.||...|....| :|.|::...:.|
Mouse   539 IVTFRPP--HYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	224/547 (41%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:444915	226/550 (41%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		10/29 (34%)