Protein Alignment ine and DAT

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: XP_061499264.1
• Gene: DAT / 1269812
• VectorBaseID: AGAMI1_006978
• Length: 678
• Species: Anopheles gambiae
• Alignment Length: 610
• Identity: 242/610 - (39%)
• Similarity: 361/610 - (59%)
• Gaps: 51/610 - (8%)

  Fly   284 GSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGV----DDDDSYLDMSDETAQLKPRQQHWANKM 344
            |.::|..|.:    ||..::.....|...|..|.    ......||..:|       ::.|:.|:
Mosquito    49 GDSEGTALAM----TTIGQIKAKGRPGLLPRNGAGGGGGGGGGELDDGEE-------RETWSGKV 102

  Fly   345 QFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGAL 409
            .|:|:.||::|.|.|||||||:|||:|||.||:||.|:|.:..|||.:|||::||:..:|.|...
Mosquito   103 DFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGGIPLFYMELALGQFNRKGAITCW 167

  Fly   410 GQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDC------- 467
            |:|.|||||.|.|.|:::|.:..||:|||.:|:.:||.||...:||..|:|.|||.:|
Mosquito   168 GRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTDSLPWTHCSNAWNTVECKPFGYIN 232

  Fly   468 ----WVPQRKGINA--------SAPDTS-RTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLI 517
                .|..|.|:.|        :..||. .:.:.|:|...:|::  |.|:...|.::|::..||:
Mosquito   233 STAATVVNRTGVLAANVTGTVSTINDTKFASAASEYFNRYILELDKSEGIHDLGAIKWDMALCLL 297

  Fly   518 CAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANV 582
            ..:|:.||:.||.|.:|.||.:|||.||:.:::||:||.:||.|:|||:.::.||.:..:.||.|
Mosquito   298 AVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLVRGITLPGSAEGILYYLRPNFDVIYNAEV 362

  Fly   583 WINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQ 647
            |::||:|.|.|||..||.::::||||||:||:.:|.:..|.:|..||.:.|...||.||.:|...
Mosquito   363 WVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSLINSATSFIAGFVIFSVLGYMAHAS 427

  Fly   648 NTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPR 712
            ..:::||..:|||::|||||.|:|.||.:..||::||.|||.|||:|.|...|.::|::.|.||:
Mosquito   428 GQSIQDVATEGPGLVFVVYPAAIATMPGSIFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK 492

  Fly   713 WIKRHLGYHEIVVLFVCVISCLF---GMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWF 774
             |.|:   .||   ||.|:..|:   |:.:..|||.|:|||:|.|||..:|:...|.:.||::|.
Mosquito   493 -IGRN---REI---FVAVLFSLYFVVGLASCTQGGFYFFQLLDRYAAGYSILIAVFFEAIAVSWI 550

  Fly   775 YGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEP-TYHNGRYTYPDWAYGI 838
            |||.|...::|.|.|.||..|.|.||..:.|..|..|.:..||. ||| :|.:  |.||.||..:
Mosquito   551 YGTERFCNDIKDMIGFAPGIYWRVCWKFVAPLFLLFIIIYGLIG-HEPLSYED--YVYPSWANVL 612

  Fly   839 GWMFASFSLICIPGYAVINFLRSSG 863
            ||..|..|:|.||..|....:.:.|
Mosquito   613 GWCIAGSSMIMIPLMASYKLIVTPG 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	231/553 (42%)
DAT	XP_061499264.1	None