DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and Slc6a9

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_006238687.1	Gene:	Slc6a9 / 116509	RGDID:	621243	Length:	638	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	234/561 - (41%)
Similarity:	342/561 - (60%)	Gaps:	33/561 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGR 403
            :|.|:::|||..:||:|||||||||||:||::|||.|:.||.|:|..|.|||.|||||.||:..:
  Rat    34 NWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQ 98

  Fly   404 GPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCW 468
            |.:| :.::.|:|||.|...:|||..:..||:|:|..:.||||:|....:||..|||.||||||
  Rat    99 GCLG-VWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDC- 161

  Fly   469 VPQRKGI-------NASAPDT-------------SRT-PSEEFFENKVLQISGGLEYPGMMRWEL 512
                .|:       |.|.|..             .|| ||||::...||::|..:...|.:|..|
  Rat   162 ----AGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPL 222

  Fly   513 FACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSEL 577
            ..||..:|::|:....:.:|||.||.|||||||:|::.||.||.|||:||..|:.::..|||.::
  Rat   223 LGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKI 287

  Fly   578 KNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGN 642
            ..|.||.:||||.|.|||..:|.:|:.|||||::||..||:|.:|..|..||:..|...||.||.
  Rat   288 LEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 352

  Fly   643 LALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQ 707
            :|.....:|..|...|||:.||.||:|:..:|.:.||:::|||||:.|||.:||.::|.:||:|.
  Rat   353 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIV 417

  Fly   708 DGF-PRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAI 771
            |.. ..||.:...|   |.|.|.|...|.|:|...|.|||:..|||:||||.:::.::....::|
  Rat   418 DEVGNEWILQKKTY---VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSI 479

  Fly   772 AWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAY 836
            .:.||.....::::.|.|..|..:.:.||..:.|.::|.|.:.::|.|...||::  |.||.||.
  Rat   480 MYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNH--YQYPGWAV 542

  Fly   837 GIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPN 877
            .||::.|..|:||||.||:....|:.|||..:|::|..:|:
  Rat   543 AIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPS 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	233/558 (42%)
Slc6a9	XP_006238687.1	SLC6sbd_GlyT1	16..599	CDD:212067	234/561 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820