DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and Slc6a5

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_006540608.1	Gene:	Slc6a5 / 104245	MGIID:	105090	Length:	831	Species:	Mus musculus

Alignment Length:	860	Identity:	289/860 - (33%)
Similarity:	447/860 - (51%)	Gaps:	141/860 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 IDDCN--EEGDAIPA---AASVP-------APVT-----MPAISPT--------PATLTCTTTTT 184
            |.||:  :|.:..||   .|:||       ||.|     :||.:||        |.:.:....|.
Mouse    32 ICDCSAPKEMNKQPANILEAAVPGHRDSPRAPRTSPEQDLPAEAPTATVQPPRVPRSASTGAQTF 96

  Fly   185 MAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPNPLYMQP 249
            .:.|:.|.               .:.:|.|     |..:.|.......|.|...|...:.....|
Mouse    97 QSADARAC---------------EAQQSGV-----GFCNLSSPRAQATSAALRDLSEGHSAQANP 141

  Fly   250 QASLSGSSYHFHELAGNQIYSDVTSVRSL---ASIGIGSTDGRKLVIRRVPTTANELFDMVNPQT 311
            .:..:|        |||.::..:.::|..   |::.:|     |..:....|.|....:|  .|:
Mouse   142 PSGPAG--------AGNALHCKIPALRGPEEDANVSVG-----KGTLEHNNTPAVGWVNM--SQS 191

  Fly   312 PPPLGVDDDDSYLDMSDETAQLKPRQQ--------HWANKMQFVLACIGYSVGLGNVWRFPYMCY 368
            ...||.|...|.|..|..|..:...:|        :|::|:.|:|:.:||:|||||||||||:.:
Mouse   192 TVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAF 256

  Fly   369 KSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTY 433
            ::|||.||:||.::|.:..:|:.|:|:|:||:..:||: ::.:..|..:|.|:|.:::|.|::.|
Mouse   257 QNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPV-SVWKAIPALQGCGIAMLIISVLIAIY 320

  Fly   434 YSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDC-----------------------------WV 469
            |:|||.|:::|.|.||.:.:||..|||.||||:|                             ..
Mouse   321 YNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAY 385

  Fly   470 PQRKGINASAPDTSRT---PSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSI 531
            |....:|.:: .|::|   .|||:|:..||:||.|:||||.:||.|..||..||::||.:..|.|
Mouse   386 PNLTMVNFTS-QTNKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGI 449

  Fly   532 KSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGI 596
            |||.||.|||||||:|:::||::|.|||.||..|:.:|..|||.:|.:|.||.:||:|.|.||..
Mouse   450 KSSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA 514

  Fly   597 TFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGM 661
            .:|.:|:.:||||::||..|||:.|:..|..||:..|...||.:|.:|.|:..|:.:|...|||:
Mouse   515 AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGI 579

  Fly   662 IFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVL 726
            .|||||:|:.::|.:..||::||.|||.|||::.||.:|.:||||.|.||::::.|   ..:..|
Mouse   580 AFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTH---KPVFTL 641

  Fly   727 FVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKA 791
            ..|:...:.|.|.|.|||||.|||:|.||||..::.:|..:::.|::.||..|..::::.|.|..
Mouse   642 GCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFK 706

  Fly   792 PSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVI 856
            |:.:.:.||..:.|.:|..|...|...:...||  |.|.||:|:..:||:..:.|:|.||...||
Mouse   707 PNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY--GSYRYPNWSMVLGWLMLACSVIWIPIMFVI 769

  Fly   857 NFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMATVYKPTNPHL----- 916
            ....:.| .|.||::....|.                |:...| |||.....||.....|
Mouse   770 KMYLAPG-RFIERLKLVCSPQ----------------PDWGPF-LAQHRGERYKNMIDPLGTSSL 816

  Fly   917 --------LNLGQKC 923
                    |.||.:|
Mouse   817 GLKLPVKDLELGTQC 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	229/578 (40%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	237/620 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920