Protein Alignment ine and slc6a5

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: XP_031756248.1
• Gene: slc6a5 / 100495275
• XenbaseID: XB-GENE-993852
• Length: 789
• Species: Xenopus tropicalis
• Alignment Length: 837
• Identity: 283/837 - (33%)
• Similarity: 434/837 - (51%)
• Gaps: 122/837 - (14%)

  Fly   160 SVPAPVTMPAI-SPTP------------ATLTCTTTTTMAGDS---VAVSPLSMEL-KSRLGSHH 207
            :.|.|:....| |.||            |.|:.:|    :.||   .|..|.:.:| :||:|...
 Frog    20 AAPGPIGAAGITSHTPDNDLPLQASSKLARLSQST----SNDSKFAAAEEPKACDLERSRIGGSC 80

  Fly   208 SSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPNPLYMQ--PQASLSGSS---YHFHELAGNQ 267
            .......|.::.......|......|||.|..|. |||:.:  |..|..|.:   :..:.|..|.
 Frog    81 KMTTPGHSNFVLKRDSVEGCPAKNTSMADSNGQT-NPLHCRIVPLQSAEGETNQGFGKNSLEQNN 144

  Fly   268 IYSDVTSVRSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQ 332
            ........:|...:|   |||...|.   |.|.|                         .||...
 Frog   145 AKGGWVPSQSTVVLG---TDGNTSVF---PGTLN-------------------------GDEEGD 178

  Fly   333 LKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSV 397
            ....:.:|::|:.|:|:.:||:|||||||||||:.:|:|||.||:||..:|.:..:|:.:||:::
 Frog   179 ENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFKNGGGAFLIPYLTMLALAGLPIFYMEVAL 243

  Fly   398 GQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRW 462
            ||:..:||| ::.:..|..:|.|:|.:::|.|::.||::|:.|:|:|.|.|..:.:||..|.|.|
 Frog   244 GQFASQGPI-SVWKAIPALQGCGIAMLIISVLIAIYYNIIMCYTIFYLFASLVSVLPWASCTNPW 307

  Fly   463 NTPDCWVPQRKGINA----SAPD---------------------TSR------TPSEEFFENKVL 496
            |||||....|..:::    |.|:                     ||.      :.|||:|:..:|
 Frog   308 NTPDCKDKDRLMLDSCIIGSQPNIHIKNSTFCMTAYPNLTLVNFTSHANKSFVSGSEEYFKYNML 372

  Fly   497 QISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDG 561
            :||.|:||||.:||.|..||..||.:||.:..|.||||.||.|||||||:|:::||::|.|||.|
 Frog   373 KISAGIEYPGEIRWPLAICLFLAWTIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPG 437

  Fly   562 AAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNM 626
            |.:|:.:|..|||.:|.:|.||.:||:|.|.||...:|.:|:.:||||::||:.|||:.|:..|.
 Frog   438 AGDGIWWFIMPKWEKLMDAMVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNVYRDTLIVTCTNS 502

  Fly   627 ITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLG 691
            .||:..|...||.:|.:|...|.::..|...|||:.|||||:|:.::|.:..||::||.|||.||
 Frog   503 ATSIFAGFVIFSVIGFMAHILNVDIEKVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLG 567

  Fly   692 LNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAA 756
            |::.||.:|.:|||:.|.||:.::.|   ..:..|..||...:.|.|.|.|||||..||:|:|||
 Frog   568 LDTMFATIETIVTSVSDEFPKLLRPH---KPLFTLICCVAFFIMGFPMITQGGIYMLQLVDNYAA 629

  Fly   757 SVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHE 821
            |.:::.:|..:::.|::.||..|..::::.|.|..||.:.:.||..:.|.:|..|...|...:..
 Frog   630 SYSLVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPSRFWKVCWAFVTPTILTFILCFSFYQWEP 694

  Fly   822 PTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGE 886
            .||  |.|.||.|:..:||:..:.|:|.||...||....:.| ||.||::....|.
 Frog   695 MTY--GSYHYPTWSMVMGWLMLACSVIWIPVMFVIKMYLAPG-TFIERLKLVCSPQ--------- 747

  Fly   887 HHCEHDYPEQEQFMLAQEMATVYKPTNPHLLNLGQKCGYNA--MQASPSHAEAGGPC 941
                   |:...| ||:.....||       |:....|.::  ::..|...|.|..|
 Frog   748 -------PDWGPF-LAKHRGERYK-------NMIDPLGTSSLGLKLPPKDFELGTQC 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	227/569 (40%)
slc6a5	XP_031756248.1	SLC6sbd_GlyT2	183..779	CDD:271389	236/626 (38%)