DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and slc6a5

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_031756248.1	Gene:	slc6a5 / 100495275	XenbaseID:	XB-GENE-993852	Length:	789	Species:	Xenopus tropicalis

Alignment Length:	837	Identity:	283/837 - (33%)
Similarity:	434/837 - (51%)	Gaps:	122/837 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 SVPAPVTMPAI-SPTP------------ATLTCTTTTTMAGDS---VAVSPLSMEL-KSRLGSHH 207
            :.|.|:....| |.||            |.|:.:|    :.||   .|..|.:.:| :||:|...
Frog    20 AAPGPIGAAGITSHTPDNDLPLQASSKLARLSQST----SNDSKFAAAEEPKACDLERSRIGGSC 80

  Fly   208 SSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPNPLYMQ--PQASLSGSS---YHFHELAGNQ 267
            .......|.::.......|......|||.|..|. |||:.:  |..|..|.:   :..:.|..|.
Frog    81 KMTTPGHSNFVLKRDSVEGCPAKNTSMADSNGQT-NPLHCRIVPLQSAEGETNQGFGKNSLEQNN 144

  Fly   268 IYSDVTSVRSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQ 332
            ........:|...:|   |||...|.   |.|.|                         .||...
Frog   145 AKGGWVPSQSTVVLG---TDGNTSVF---PGTLN-------------------------GDEEGD 178

  Fly   333 LKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSV 397
            ....:.:|::|:.|:|:.:||:|||||||||||:.:|:|||.||:||..:|.:..:|:.:||:::
Frog   179 ENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFKNGGGAFLIPYLTMLALAGLPIFYMEVAL 243

  Fly   398 GQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRW 462
            ||:..:||| ::.:..|..:|.|:|.:::|.|::.||::|:.|:|:|.|.|..:.:||..|.|.|
Frog   244 GQFASQGPI-SVWKAIPALQGCGIAMLIISVLIAIYYNIIMCYTIFYLFASLVSVLPWASCTNPW 307

  Fly   463 NTPDCWVPQRKGINA----SAPD---------------------TSR------TPSEEFFENKVL 496
            |||||....|..:::    |.|:                     ||.      :.|||:|:..:|
Frog   308 NTPDCKDKDRLMLDSCIIGSQPNIHIKNSTFCMTAYPNLTLVNFTSHANKSFVSGSEEYFKYNML 372

  Fly   497 QISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDG 561
            :||.|:||||.:||.|..||..||.:||.:..|.||||.||.|||||||:|:::||::|.|||.|
Frog   373 KISAGIEYPGEIRWPLAICLFLAWTIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPG 437

  Fly   562 AAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNM 626
            |.:|:.:|..|||.:|.:|.||.:||:|.|.||...:|.:|:.:||||::||:.|||:.|:..|.
Frog   438 AGDGIWWFIMPKWEKLMDAMVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNVYRDTLIVTCTNS 502

  Fly   627 ITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLG 691
            .||:..|...||.:|.:|...|.::..|...|||:.|||||:|:.::|.:..||::||.|||.||
Frog   503 ATSIFAGFVIFSVIGFMAHILNVDIEKVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLG 567

  Fly   692 LNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAA 756
            |::.||.:|.:|||:.|.||:.::.|   ..:..|..||...:.|.|.|.|||||..||:|:|||
Frog   568 LDTMFATIETIVTSVSDEFPKLLRPH---KPLFTLICCVAFFIMGFPMITQGGIYMLQLVDNYAA 629

  Fly   757 SVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHE 821
            |.:::.:|..:::.|::.||..|..::::.|.|..||.:.:.||..:.|.:|..|...|...:..
Frog   630 SYSLVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPSRFWKVCWAFVTPTILTFILCFSFYQWEP 694

  Fly   822 PTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGE 886
            .||  |.|.||.|:..:||:..:.|:|.||...||....:.| ||.||::....|.
Frog   695 MTY--GSYHYPTWSMVMGWLMLACSVIWIPVMFVIKMYLAPG-TFIERLKLVCSPQ--------- 747

  Fly   887 HHCEHDYPEQEQFMLAQEMATVYKPTNPHLLNLGQKCGYNA--MQASPSHAEAGGPC 941
                   |:...| ||:.....||       |:....|.::  ::..|...|.|..|
Frog   748 -------PDWGPF-LAKHRGERYK-------NMIDPLGTSSLGLKLPPKDFELGTQC 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	227/569 (40%)
slc6a5	XP_031756248.1	SLC6sbd_GlyT2	183..779	CDD:271389	236/626 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010