Protein Alignment ine and slc6a6

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: XP_017949178.2
• Gene: slc6a6 / 100494063
• XenbaseID: XB-GENE-991256
• Length: 616
• Species: Xenopus tropicalis
• Alignment Length: 562
• Identity: 237/562 - (42%)
• Similarity: 352/562 - (62%)
• Gaps: 24/562 - (4%)

  Fly   328 DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLF 392
            ||.....|:::.||:|:.|||:..|..:||||||||||:|||:|||.||:||.|.||...:|:.|
 Frog    32 DEADGKPPQREKWASKIDFVLSVAGGFIGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFF 96

  Fly   393 MELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWID 457
            :|:.:||:|..|.|....::||:|.|.|.||:|:..|::.||.||:.:.:||.|.||:.::||..
 Frog    97 LEVVLGQFTSEGGITCWEKICPVFTGIGYASIVIVSLLNVYYIVILAWGVYYLFQSFQGQLPWAL 161

  Fly   458 CNNRWNTPDC-----------WVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWE 511
            |:..|||..|           |: .....|.::|.|      ||:|:|||.:|.|::..|:::|:
 Frog   162 CHQPWNTESCVEDTFRKNWTMWM-SMNSTNFTSPVT------EFWEHKVLSLSKGIDDVGVLKWD 219

  Fly   512 LFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSE 576
            |..||:..|::.:|..||.::|:.||.||||||||:::::|::|.|||.|||||::|:..|..:.
 Frog   220 LALCLLLTWVICFFCIWKGVRSTGKVVYFTATFPFIMLLVLLIRGVTLPGAAEGIKFYLYPDITR 284

  Fly   577 LKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLG 641
            |.:..|||:|.:|.|.|..|..|:|.|..|||||..|..||.:.:..:|..||.:.|...||.||
 Frog   285 LADPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCMLLGCLNSGTSFVSGFAIFSVLG 349

  Fly   642 NLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSI 706
            .:|.||..::.||...|||:.|:.||:|::.||....||::||.|||.|||:|||..||..:||:
 Frog   350 FMAQEQGVDIADVAESGPGLAFIAYPKAVSMMPLPSFWAILFFIMLLLLGLDSQFVEVEGQITSL 414

  Fly   707 QDGFPRWIKRHLGY-HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMI 769
            .|.:|.::::  || .||.:..||.:|.|.|:..:.:||:|.|||.|:|||| |.::::||.:.:
 Frog   415 VDLYPSFLRK--GYRREIFIAVVCFLSYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECV 477

  Fly   770 AIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDW 834
            |:||.||..:...|::.|.|..|..:::..|.|:.|.|..|.::.||..|...|| |..|.||||
 Frog   478 AVAWVYGADKFYDNIEDMIGYKPGPWMKWSWTVITPLLCVACFIFSLAKYTPLTY-NKYYVYPDW 541

  Fly   835 AYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP 876
            |.|:||:.|..|:||||...|.:.:||.|... |||:....|
 Frog   542 AIGLGWVLALSSMICIPLVVVFHIVRSDGSLI-ERIKAVTAP 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	233/551 (42%)
slc6a6	XP_017949178.2	SLC6sbd_TauT	41..582	CDD:271398	233/551 (42%)