DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and slc6a4

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_017946918.1	Gene:	slc6a4 / 100493853	XenbaseID:	XB-GENE-22062972	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	736	Identity:	242/736 - (32%)
Similarity:	392/736 - (53%)	Gaps:	90/736 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 PAPVTMPAISPTPATLTCTTTTTMAGDSVAV---SPLSMELKSRLGSHHSSMRSVVSGYLPGLSD 223
            |..:..|::......|||...:....|...:   .| |:.|...|...|.|         ||...
Frog     5 PTCIESPSLGSEKEPLTCRARSECKKDGQLLRNCKP-SLRLSEELNKVHPS---------PGERG 59

  Fly   224 SSGNLVGGVSMATSGLQAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLASIGIGSTDG 288
            ..|:    :|.....:|:       |:|..:|                   :|:      |..:|
Frog    60 EPGH----ISNKYLAVQS-------PEAPCNG-------------------MRN------GGDEG 88

  Fly   289 RKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGY 353
            ....:..:|....|:..:   ||  .:|                   .::.|:.|:.|:|:.|||
Frog    89 STPTLTVLPACRAEIQHL---QT--EIG-------------------ERETWSKKIDFLLSVIGY 129

  Fly   354 SVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKG 418
            :|.|||||||||:||::|||.||:||.|:.....|||.:|||::|||...|.|....::||||||
Frog   130 AVDLGNVWRFPYVCYQNGGGAFLIPYVIMAVFGGIPLFYMELAMGQYHRNGCISIWRKICPLFKG 194

  Fly   419 AGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCW-VPQRKGINASAPDT 482
            .|.|..:::..::.||:.|:.:::||...||::|:||..|.|.|||.:|. ..|...:..|  ::
Frog   195 IGYAICMIALYVAFYYNTIMAWALYYLIFSFRSELPWTSCLNEWNTGNCTNYFQNSSVGWS--NS 257

  Fly   483 SRTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFP 545
            |.:|:|||:...||||  |.||...|.:.|:|..||:..:.:|||:.||.:|:|.||.:.|||||
Frog   258 SISPAEEFYTRLVLQIHKSKGLHDLGGISWQLTLCLLLIFTVVYFSIWKGVKTSGKVVWVTATFP 322

  Fly   546 FVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKY 610
            ::::.:|::|..||.||..|:.|:.:|.|.:|....||::||:|.|.|||..||.:::||||||:
Frog   323 YIVLALLLIRGATLPGAWRGVLFYLQPDWEKLLTTAVWVDAAAQIFFSLGPGFGVLLAFASYNKF 387

  Fly   611 NNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGD-GPGMIFVVYPQAMAKMP 674
            :||..:|.:..|.||.:||.:.|:..|:.||.:|..:|.:|.:|..| ||.::|:.|.:|:|.||
Frog   388 HNNCYQDALITSTVNCMTSFMSGLVIFTVLGYMAEMRNLDVSEVAKDTGPSLLFITYAEAIANMP 452

  Fly   675 YAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPR-WIKRHLGYHEIVVLFVCVISCLFG-M 737
            .:..:|::||.||:.|||:|.||.:|.|:|::.|.||. |.||    .|:.| |:.:..|..| :
Frog   453 ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWGKR----RELFV-FLLISVCFLGAL 512

  Fly   738 PNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLV 802
            ..:..||.|..:|.:.||....::.:.|.:.||::||||..:..::|::|.|.:|.::.:.||:.
Frog   513 STLTFGGAYMVKLFEEYATGPAVLTVVFLEAIAVSWFYGINQFCRDVREMLGFSPGWFWKICWVA 577

  Fly   803 LGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFW 867
            :  |.||.::::.......|......|.||.|...:|:...:.|.||:|.| ::..|.|:..:..
Frog   578 I--CPLFLLFIICSFMSSPPDLRLFNYQYPSWTVVLGYCIGTSSFICVPAY-MVYLLTSTPGSIK 639

  Fly   868 ERIRNTLRPNI-YECKICGEH 887
            ||...::.|.: .|..:.|.|
Frog   640 ERFLKSITPEVSREIPLGGIH 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	210/544 (39%)
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:367522	14/87 (16%)
slc6a4	XP_017946918.1	SLC5-6-like_sbd	113..649	CDD:382020	210/545 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010