Protein Alignment ine and slc6a3

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: XP_002933174.1
• Gene: slc6a3 / 100488824
• XenbaseID: XB-GENE-982873
• Length: 621
• Species: Xenopus tropicalis
• Alignment Length: 593
• Identity: 238/593 - (40%)
• Similarity: 363/593 - (61%)
• Gaps: 34/593 - (5%)

  Fly   316 GVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYC 380
            ||...:|.|....:.......::.|:.|:.|:|:.||::|.|.|||||||:|||:|||.|||||.
 Frog    39 GVQFTNSALVSPSQINTENGERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYI 103

  Fly   381 IILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYF 445
            ..:.|..:||.:|||::||:...|..| :.::||:|||.|...:::|..:..:|:|||.:::.|.
 Frog   104 FFMVIAGMPLFYMELALGQFNREGAAG-VWKICPIFKGVGYTVILISLYVGFFYNVIIAWALQYL 167

  Fly   446 FTSFKTEMPWIDCNNRWNTPDCWVPQRK----------GINASAPDTSR-TPSEEFFENKVLQI- 498
            |:||.:|:|||.|||.||:|:|  .:.|          |:|    ||.: ||:.|:||..||.:
 Frog   168 FSSFTSELPWIHCNNSWNSPNC--SETKYSNFSDYSLFGLN----DTYKVTPAAEYFERGVLHLH 226

  Fly   499 -SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGA 562
             |.|:...|..||:|.:|||...:.:||:.||.:|:|.||.:.|||.|:|::..|::|.|||.||
 Frog   227 ESQGIHDLGSPRWKLTSCLIVVIVFLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGA 291

  Fly   563 AEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMI 627
            .:|::.:....:..|..|:|||:||:|...|||:.||.:|:|:||||:.||..||.:..::||.:
 Frog   292 IDGIKAYLSVDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSVNSL 356

  Fly   628 TSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGL 692
            ||...|...||.||.:|.:.|..:.||..||||:||::||:|:|.:|.:.:|:|:||.|||.||:
 Frog   357 TSFFSGFVIFSFLGYMAQKHNVPIGDVAKDGPGLIFIIYPEAIATLPLSSVWSVIFFIMLLTLGI 421

  Fly   693 NSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS 757
            :|....:|.|:|.:.|.| ::::||   .|:..||:.:.:....:..:..||||.|.|:||:||.
 Frog   422 DSAMGGMESVITGLIDEF-KFLRRH---RELFTLFIVLCTFFTSLSCVTNGGIYVFTLLDHFAAG 482

  Fly   758 VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEP 822
            .:|:|....:.|.||||||.||.|.::::|.||.|..|.|.||..:.||.|..:.|:|::.|..|
 Frog   483 TSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGKRPGLYWRLCWKFVSPCFLLFVVVVSIVTYRSP 547

  Fly   823 TYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP-NIYECKICGE 886
            .|  |.||:|:||..|||:.|..|:..:|.||:..|....| :|.|:|...:.| ..||....|:
 Frog   548 KY--GNYTFPEWANVIGWLVAISSMAMVPLYAIYKFSSLHG-SFREKIAYAITPEKEYELIESGK 609

  Fly   887 ------HH 888
                  ||
 Frog   610 IRQFTLHH 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	228/551 (41%)
slc6a3	XP_002933174.1	SLC6sbd_DAT1	60..615	CDD:212083	232/568 (41%)