DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and slc6a13

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_002667408.5	Gene:	slc6a13 / 100332592	ZFINID:	ZDB-GENE-170607-2	Length:	621	Species:	Danio rerio

Alignment Length:	615	Identity:	247/615 - (40%)
Similarity:	374/615 - (60%)	Gaps:	32/615 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 QLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELS 396
            ::|.|.| |:||::|||:..|..:||||||||||:|||:|||.|.:||.|.||.|.||:.|:|:|
Zfish    26 KMKDRGQ-WSNKLEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLEIS 89

  Fly   397 VGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNR 461
            :||||..|.|....::.|||:|.|.|:.|:..|::.||.:::.:.|:|...||...:||..|||.
Zfish    90 LGQYTSEGGITCWRKISPLFEGIGYATQVIVALLNFYYIIVLAWGIFYLSNSFTWNLPWSSCNNT 154

  Fly   462 WNTPDCWVPQRK--GINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVY 524
            |||..|...||:  .::.|..|.:.:|..||:|.:||:||.|:|..|.:.|:|..||:.||::.|
Zfish   155 WNTESCMEFQRRNDSVDQSYLDNATSPVIEFWERRVLRISSGIEDIGTLHWDLVLCLLLAWVLCY 219

  Fly   525 FATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQ 589
            |..||.:||:.||.|||||||:|:::||::|.|||.||:.|::|:..|....|.:..||::|.:|
Zfish   220 FCIWKGVKSTGKVVYFTATFPYVMLLILLIRGVTLPGASRGIQFYLYPDLGRLADPQVWMDAGTQ 284

  Fly   590 NFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDV 654
            .|.|..|..|.:.:..||||||||..||::|:..:|..||.:.|...||.||.::.|||..:.:|
Zfish   285 IFFSYAICLGCLTALGSYNKYNNNCYRDSLALCFLNSGTSFVAGFAIFSILGFMSYEQNVPISEV 349

  Fly   655 IGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLG 719
            ...|||:.|:.||:|::.||.:.|||..||.|::.|||:|||..||.:||::.|.:|.:.:|. .
Zfish   350 AESGPGLAFIAYPRAVSMMPISPLWACFFFIMIVLLGLDSQFVCVESLVTAMVDMYPSFFRRK-N 413

  Fly   720 YHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKN 783
            ..|:::|.|.::|.|.|:..:.:||:|.|||.|:|||| :.::|:|..:.:.|||.||..|...|
Zfish   414 RRELLILVVAIVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETVCIAWIYGANRFYDN 478

  Fly   784 VKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLI 848
            ::.|.|..|..|::.|||...|...|..:..|||.| .|..:|..|.||.|.|.:|||.|..|:|
Zfish   479 IEDMIGYRPGPYIKYCWLFFTPATCFGTFAFSLIKY-TPLKYNNEYVYPWWGYALGWMLALSSMI 542

  Fly   849 CIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYP----EQE--QFMLAQEMAT 907
            |:|.:.:.....:.| :..||::..:||:             .|.|    |||  |.:.:.:..:
Zfish   543 CVPLWVIYRMGTTKG-SLMERVQFLIRPS-------------PDLPKSRREQEKLQAVFSADGDS 593

  Fly   908 VYK---PTNPHLLNLGQKCGYNAMQASPSH 934
            :::   .|:.|..|   :.||..::...||
Zfish   594 LHQHSTHTHSHTHN---RDGYFPVREKESH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	230/541 (43%)
slc6a13	XP_002667408.5	SLC6sbd-TauT-like	30..569	CDD:271387	231/542 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820