DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and si:ch211-132b12.1

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001076533.1	Gene:	si:ch211-132b12.1 / 100034467	ZFINID:	ZDB-GENE-050420-315	Length:	586	Species:	Danio rerio

Alignment Length:	550	Identity:	222/550 - (40%)
Similarity:	341/550 - (62%)	Gaps:	9/550 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGR 403
            :|.:||:|:||..|..|||||||||||:|||.|||.||:||.:.:..|.:||..:|:::||||.:
Zfish    13 YWGSKMEFLLAVAGNVVGLGNVWRFPYLCYKYGGGAFLIPYLVFVVTCGVPLFLLEMAMGQYTQQ 77

  Fly   404 GPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDC- 467
            |.:....:||||.:|.|....::......||.||:.::::|...|||:::||..|:|.|||.||
Zfish    78 GGVTCWHRLCPLAEGIGYGGQLILLYSCMYYIVILAWALFYLIFSFKSQLPWATCDNTWNTDDCI 142

  Fly   468 -WVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSI 531
             .|.:...||.::...|...:.||:|.:||.:|||:|..|.:.||:..|||..|::.||..||.:
Zfish   143 NLVTKNLTINRTSLINSTPAATEFWERRVLSLSGGIEDIGKINWEILLCLIAMWIICYFCVWKGV 207

  Fly   532 KSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGI 596
            ||:.||.|||||||:|::::|::|.:||.||.:|:.|:..|:.:.|.:..||:.|.:|...|..:
Zfish   208 KSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWLEAGTQILFSYSV 272

  Fly   597 TFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGM 661
            :.||:...||||||:||..||.:.:..:|.:||.:.|...|:.||.:|.||...:.:|...|||:
Zfish   273 SVGSITVLASYNKYHNNCYRDCLGLCLLNSVTSFVAGFAVFTVLGFMAQEQGVPIEEVAESGPGL 337

  Fly   662 IFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVL 726
            .|:.||||:|.||:.|||||.||.|::.|||::||..:|.||||:.|.||..::|. |..||::|
Zfish   338 AFIAYPQAVAMMPFPQLWAVCFFIMIILLGLDTQFVSMEAVVTSVMDMFPVVLRRE-GRREILLL 401

  Fly   727 FVCVISCLFG-MPNIIQGGIYYFQLMDHYAASVT-IMFLAFCQMIAIAWFYGTGRLSKNVKQMTG 789
            |.| ::|.|| ...:.:||:|.|||.|:||.:.| ::||:..:.:.:.|.:|..||...::.||.
Zfish   402 FFC-LTCFFGQFIMVTEGGMYVFQLFDYYACNGTCLLFLSVFESLTMGWIFGADRLFDIIEDMTK 465

  Fly   790 KAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYA 854
            ..|::....||..|.|.:....:|.|::.| :|...|..|.:|||||.:||:.|..|::.:||:|
Zfish   466 SRPNYIFMLCWKYLTPLVSLVCFVCSMVEY-QPLTFNRWYVFPDWAYVLGWLLALSSIVLVPGWA 529

  Fly   855 VINFLRSSGD--TFWERIRNTLRPNIYECK 882
            :.......|.  ..|.|:.:..:.....||
Zfish   530 LGRLCSEKGSLKQRWRRLCSADKDLPLTCK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	220/542 (41%)
si:ch211-132b12.1	NP_001076533.1	SLC6sbd-TauT-like	11..549	CDD:271387	220/538 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820