DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and si:ch211-132b12.3

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001076419.1	Gene:	si:ch211-132b12.3 / 100002232	ZFINID:	ZDB-GENE-050419-161	Length:	577	Species:	Danio rerio

Alignment Length:	521	Identity:	211/521 - (40%)
Similarity:	324/521 - (62%)	Gaps:	9/521 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 WANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRG 404
            |..|.:|:||..|..||:||||||||:||::||||||:||.:.:..|.:||..:|..:||:|..|
Zfish    14 WGRKAEFLLAVAGNVVGVGNVWRFPYLCYRNGGGVFLIPYLVFVMTCGVPLFLLETVMGQFTHEG 78

  Fly   405 PIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWV 469
            .|.....||||.:|.|.|..::......|:::|:.::::|...||.:::||..|:|.|||.:| |
Zfish    79 GITCWHLLCPLAQGVGYAGQLIELYSCMYFTIILAWALFYLIFSFSSQLPWASCDNIWNTDNC-V 142

  Fly   470 PQRKG---INASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSI 531
            ....|   .|.:....|.:.:.||:|.:||.:|||:|..|.:.||:..||...|::.||..||.:
Zfish   143 NLAAGNLTFNRTTQINSTSAATEFWERRVLSLSGGIEEIGKINWEIALCLFVMWIICYFCIWKGV 207

  Fly   532 KSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGI 596
            ||:.||.|||||||:|::::|::|.:||.||.:|:.|:..|:.:.|.:..||:.|.:|.|.|..:
Zfish   208 KSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPAHLADPQVWMEAGTQVFFSYSL 272

  Fly   597 TFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGM 661
            ..|.:|:..|||:|:||..||:..:..:|..||.:.|...||.||.:|..|...|.:|...|||:
Zfish   273 CSGILIALGSYNQYSNNCYRDSFWLCLLNSGTSFVAGFAVFSVLGFMAHVQGVPVEEVAESGPGL 337

  Fly   662 IFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVL 726
            .|:.||||:|.||:.|||||.||.|::.|||:|||..:|.||||:.|.||. :.|..|..|:.||
Zfish   338 AFIAYPQAVAMMPFPQLWAVCFFIMIILLGLDSQFVAMECVVTSVTDLFPE-VLRRAGRRELFVL 401

  Fly   727 FVCVISCLFG-MPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTG 789
            .:| ::|.|| :..:.:||:|.|||.|:||:: ...:||:..:.:.|.|.:|..::...:|.||.
Zfish   402 LLC-LTCFFGQLIMVTEGGMYVFQLFDNYASNGACFLFLSVFESLTIGWIFGAEKMFDIIKDMTE 465

  Fly   790 KAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYA 854
            ..|:::...||..|.|.:....:|.|::.|...|| |..|.|||||:.:||:.|..|::.:||:|
Zfish   466 SRPNYWFMLCWKYLTPLVSLTSFVYSMVRYTPLTY-NRWYVYPDWAHVLGWLLALSSILLVPGWA 529

  Fly   855 V 855
            :
Zfish   530 L 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	211/521 (40%)
si:ch211-132b12.3	NP_001076419.1	SLC6sbd-TauT-like	11..550	CDD:271387	211/521 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820