DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and SYNJ1

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_003886.3	Gene:	SYNJ1 / 8867	HGNCID:	11503	Length:	1612	Species:	Homo sapiens

Alignment Length:	556	Identity:	157/556 - (28%)
Similarity:	235/556 - (42%)	Gaps:	130/556 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASLSGS---------PKVTSAYGVLGFVRFLEG 96
            |.|:...|.....|..|..|           ||.||.:         .||..|||:||.:|...|
Human    57 FSLIVETRHKEECLMFESGA-----------VAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLG 110

  Fly    97 ----YYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV--NEVTSQRPPHPHEDRYKRMFQNIDLRSN 155
                :||:|||.   |..:|:     |:::.:.||  .|..|.|.....|||...:.:.:: ..|
Human   111 DTMLHYLVLVTG---CMSVGK-----IQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLN-SGN 166

  Fly   156 FYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFV 220
            |||::|..               |..:||..:               ||..:.   ...:..||.
Human   167 FYFAWSAS---------------GISLDLSLN---------------AHRSMQ---EQTTDNRFF 198

  Fly   221 WNAYLLQPME--GIMLKDWLLEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQ 283
            ||..|...::  |:...||||.:..|.|....|....:....||::|.|...|||||..||.|..
Human   199 WNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDD 263

  Fly   284 GDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDI--------CDPYAQT 340
            |.|||.|||||:|.....:.:|.|:|||:|..|.|        |.:|:..        .:..|..
Human   264 GHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQ--------PGLQVGSHRVRMSRGFEANAPA 320

  Fly   341 PSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFLPPPHR--MKHIHFDMA 403
            ...||..|...||..:| :||:..:|   .|.::||..:..::      ...|.  ::.::||.
Human   321 FDRHFRTLKNLYGKQII-VNLLGSKE---GEHMLSKAFQSHLK------ASEHAADIQMVNFDY- 374

  Fly   404 RQSRLSGGNVMEQLAIHAESIVQ--MTGMFFKAAGSE-PGLQTGIVRTNCVDCLDRTNSAQFAIG 465
             ...:.||.. |:|....:..||  :...||...||| ...|:|.|||||:||||||||.|..:|
Human   375 -HQMVKGGKA-EKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLG 437

  Fly   466 KCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEE----HGDTLALQYGGSQLVH---RIKTYRK 523
            ...|..|||.||..:..:|      ||..:.::..    :||:::..|.|:..:.   ::|
Human   438 LEMLAKQLEALGLAEKPQL------VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLK---- 492

  Fly   524 TAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFL 559
                     |..::::|...|.|.|:.||.:|::.|
Human   493 ---------DGARSVTRTIQNNFFDSSKQEAIDVLL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	157/556 (28%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	93/339 (27%)
SYNJ1	NP_003886.3	Syja_N	99..379	CDD:280532	93/341 (27%)
		INPP5c_Synj1	572..907	CDD:197332
		DUF1866	906..1047	CDD:286093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920