Protein Alignment FIG4 and SYNJ1

DIOPT Version :10

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_003886.3
• Gene: SYNJ1 / 8867
• HGNCID: 11503
• Length: 1612
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 157/556 - (28%)
• Similarity: 235/556 - (42%)
• Gaps: 130/556 - (23%)

  Fly    41 FRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASLSGS---------PKVTSAYGVLGFVRFLEG 96
            |.|:...|.....|..|..|           ||.||.:         .||..|||:||.:|...|
Human    57 FSLIVETRHKEECLMFESGA-----------VAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLG 110

  Fly    97 ----YYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV--NEVTSQRPPHPHEDRYKRMFQNIDLRSN 155
                :||:|||.   |..:|:     |:::.:.||  .|..|.|.....|||...:.:.:: ..|
Human   111 DTMLHYLVLVTG---CMSVGK-----IQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLN-SGN 166

  Fly   156 FYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFV 220
            |||::|..               |..:||..:               ||..:.   ...:..||.
Human   167 FYFAWSAS---------------GISLDLSLN---------------AHRSMQ---EQTTDNRFF 198

  Fly   221 WNAYLLQPME--GIMLKDWLLEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQ 283
            ||..|...::  |:...||||.:..|.|....|....:....||::|.|...|||||..||.|..
Human   199 WNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDD 263

  Fly   284 GDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDI--------CDPYAQT 340
            |.|||.|||||:|.....:.:|.|:|||:|..|.|        |.:|:..        .:..|..
Human   264 GHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQ--------PGLQVGSHRVRMSRGFEANAPA 320

  Fly   341 PSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFLPPPHR--MKHIHFDMA 403
            ...||..|...||..:| :||:..:|   .|.::||..:..::      ...|.  ::.::||.
Human   321 FDRHFRTLKNLYGKQII-VNLLGSKE---GEHMLSKAFQSHLK------ASEHAADIQMVNFDY- 374

  Fly   404 RQSRLSGGNVMEQLAIHAESIVQ--MTGMFFKAAGSE-PGLQTGIVRTNCVDCLDRTNSAQFAIG 465
             ...:.||.. |:|....:..||  :...||...||| ...|:|.|||||:||||||||.|..:|
Human   375 -HQMVKGGKA-EKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLG 437

  Fly   466 KCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEE----HGDTLALQYGGSQLVH---RIKTYRK 523
            ...|..|||.||..:..:|      ||..:.::..    :||:::..|.|:..:.   ::|
Human   438 LEMLAKQLEALGLAEKPQL------VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLK---- 492

  Fly   524 TAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFL 559
                     |..::::|...|.|.|:.||.:|::.|
Human   493 ---------DGARSVTRTIQNNFFDSSKQEAIDVLL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	Syja_N	85..407	CDD:460545	93/339 (27%)
SYNJ1	NP_003886.3	COG5329	73..519	CDD:227637	152/538 (28%)
		INPP5c_Synj1	572..907	CDD:197332
		DUF1866	906..1047	CDD:286093
		Atrophin-1	1049..>1426	CDD:460830