Protein Alignment FIG4 and INP53

DIOPT Version :10

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_014752.3
• Gene: INP53 / 854276
• SGDID: S000005635
• Length: 1107
• Species: Saccharomyces cerevisiae
• Alignment Length: 855
• Identity: 195/855 - (22%)
• Similarity: 320/855 - (37%)
• Gaps: 258/855 - (30%)

  Fly    43 LLTIDRLAHN--------RLSIEENANEFNSLEIR--RFVASLSGSPK---------VTSAYGVL 88
            |..|:.|..|        ||:..|.......:|:.  .||.:::|..|         |...:.|.
Yeast    36 LCAIELLQKNDLKKYGFKRLTSHEIFGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVD 100

  Fly    89 GFV------RFLE----GYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVTSQRPPHPHEDRY 143
            .|.      .|:|    ||.:|..|..                      .|.....|.||..: .
Yeast   101 FFCLNDNSWDFIEIDSSGYPVLPETAS----------------------TEYQDALPKHPCYE-L 142

  Fly   144 KRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVD 208
            |::..|    .:||:|..:|||.|||:     |..|                            .
Yeast   143 KKLLSN----GSFYYSSDFDLTSTLQH-----RGYG----------------------------Q 170

  Fly   209 YAFRSDS-RKRFVWNAYLLQPMEGIMLKD--------------WLLEVTHGFVSQSCISIFGRHV 258
            ::..:|: .:.::||::|:|.|  |..:|              :|..|..||.......:....|
Yeast   171 HSLSTDTYEEEYMWNSFLMQEM--ITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLKV 233

  Fly   259 NVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKM 323
            .:.:::::|.:.|||||..||.:.:.:|||.||||.|:...|...||||:|||||..|.|..|.:
Yeast   234 ALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYCYAFTQIRGSIPVFWEQGTSLI 298

  Fly   324 VPKPQI--QLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLN 386
            .|:.||  ..:...|....   |..:.:..|| |:.::||:..:         |.|:|.|.|| .
Yeast   299 NPRVQITRSFEATQPVFDK---HIMKSVEKYG-PVHVVNLLSTK---------SSEIELSKRY-K 349

  Fly   387 QFLPPPHRM---KHI---HFDMARQSRLSG-GNVMEQLAIHAESIVQMTGMFFKAAGSEPGL--Q 442
            :.|....::   |.|   .||..:::...| ..|.:.:.:..:|::. :|.:......:..:  |
Yeast   350 EHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLS-SGYYSYDVREKKNISEQ 413

  Fly   443 TGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLAL 507
            .||.||||:|||||||.||..|...|....||....:.|.....|.|.|:....|:.:|||.::.
Yeast   414 HGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQ 478

  Fly   508 QYGGSQLVHRIKTYRKTAPWGSQG--SDVMQTLSRYYSNTFSDTEKQHSINLFLG--IYKPSLTK 568
            .|.|:..:.  .::.:.......|  ||..:::||.|.|.|.|.|||.:|:..||  .|:.::..
Yeast   479 IYTGTNALK--SSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQL 541

  Fly   569 QGPPIWELQTDYDMHNAFVPRADSKAITDWVRHKVRACLPYSCADSNKLVKELFRVHSSGLEMID 633
            ..|                       :.::|..|:::.       |:|...      :|.:.::.
Yeast   542 YDP-----------------------VNEYVSTKLQSM-------SDKFTS------TSNINLLI 570

  Fly   634 AYSNYHQSFKWTDFSEHIAFEISQLALRYMPTFRTNFSP------FQRQIQTSRKARQNPSMTGQ 692
            ...|.:.:.|..|.|:.: |.|.:           .|.|      .|..|:.
Yeast   571 GSFNVNGATKKVDLSKWL-FPIGE-----------KFKPDIVVLGLQEVIEL------------- 610

  Fly   693 SSTGS-MNSNSSSSSEGDDSSSD--------------EELS------------ASFAEKEANQTE 730
             |.|| :|::.|.||..::...|              |:::            |.:.::....|:
Yeast   611 -SAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATK 674

  Fly   731 STEPAAATLATGLPSMEEIYG----CTINPPSKQSMAVYKKYVQMGKLSSGGARPAQTAVAQRDQ 791
            .|.........|..|:...||    |.:|                ..|::|.     |.|.:|..
Yeast   675 KTGFRGMAGNKGAVSIRFEYGATSFCFVN----------------SHLAAGA-----TNVEERRS 718

  Fly   792 ELAKIMRGIT 801
            :...|:||||
Yeast   719 DYESIVRGIT 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	Syja_N	85..407	CDD:460545	88/354 (25%)
INP53	NP_014752.3	COG5329	1..603	CDD:227637	165/693 (24%)
		INPP5c_ScInp51p-like	566..858	CDD:197324	38/210 (18%)