DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and Synj1

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	XP_038944618.1	Gene:	Synj1 / 85238	RGDID:	69434	Length:	1609	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	153/552 - (27%)
Similarity:	227/552 - (41%)	Gaps:	119/552 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASLSGS---------PKVTSAYGVLGFVRFLEG 96
            |.|:...|.....|..|..|           ||.||.:         .||..|||:||.:|...|
  Rat    58 FSLIVETRHKEECLMFESGA-----------VAVLSSAEKEAIKGTYAKVLDAYGLLGVLRLNLG 111

  Fly    97 ----YYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV--NEVTSQRPPHPHEDRYKRMFQNIDLRSN 155
                :||:|||.   |..:|:     |:::.:.||  .|..|.|.....|||...:.:.:: ..|
  Rat   112 DTMLHYLVLVTG---CMSVGK-----IQESEVFRVTSTEFISLRVDASDEDRISEVRKVLN-SGN 167

  Fly   156 FYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFV 220
            |||::|..               |..:||..:               ||..:.   ...:..||.
  Rat   168 FYFAWSAS---------------GVSLDLSLN---------------AHRSMQ---EHTTDNRFF 199

  Fly   221 WNAYLLQPME--GIMLKDWLLEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQ 283
            ||..|...::  |:...||||.:..|.|....|....:....||::|.|...|||||..||.|..
  Rat   200 WNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDD 264

  Fly   284 GDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDI--------CDPYAQT 340
            |.|||.|||||::.....:.:|.|:|||:|..|.|        |.:|:..        .:..|..
  Rat   265 GHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQ--------PGLQVGSHRVRMSRGFEANAPA 321

  Fly   341 PSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQ 405
            ...||..|...||.. |::||:..:|   .|.::||..:       ..|........||......
  Rat   322 FDRHFRTLKDLYGKQ-IVVNLLGSKE---GEHMLSKAFQ-------SHLKASEHASDIHMVSFDY 375

  Fly   406 SRLSGGNVMEQLAIHAESIVQM---TGMFFKAAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKC 467
            .::..|...|:|....:..||.   .|.|:....:....|:|.|||||:||||||||.|..:|..
  Rat   376 HQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFDGSAVQRCQSGTVRTNCLDCLDRTNSVQAFLGLE 440

  Fly   468 ALGHQLERLGFVKSAKLEFDSDCVTMLENLYEE----HGDTLALQYGGS-QLVHRIKTYRKTAPW 527
            .|..|||.||..:..:|      ||..:.::..    :||:::..|.|: .|..:.|
  Rat   441 MLAKQLEALGLAEKPQL------VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK-------- 491

  Fly   528 GSQGSDVMQTLSRYYSNTFSDTEKQHSINLFL 559
            ..:..|..::::|...|.|.|:.||.:|::.|
  Rat   492 AGKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	153/552 (28%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	92/337 (27%)
Synj1	XP_038944618.1	COG5329	100..523	CDD:227637	139/497 (28%)
		INPP5c_Synj1	576..911	CDD:197332
		RRM_SF	910..1052	CDD:418427
		PHA03247	<1097..1498	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920