DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and Synj2

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_001106842.1	Gene:	Synj2 / 84018	RGDID:	69436	Length:	1496	Species:	Rattus norvegicus

Alignment Length:	818	Identity:	186/818 - (22%)
Similarity:	283/818 - (34%)	Gaps:	263/818 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EIRRFVASLSGSPKVTSAYGVLGFVRFLEG----YYLLLVTKRKCCAHIGR---HLVYTIKDTVM 124
            |.:..:..|.|.|  |.|||.||.:....|    .:|:|||.   |..:||   ..:|.|..|..
  Rat    45 EEKEVIKGLYGKP--TDAYGCLGELSLKSGGVPLSFLVLVTG---CTSVGRIPDAEIYKITGTEF 104

  Fly   125 VRVNEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDL----- 184
            ..:.|...:      |||...: :.|.....|||::..|               ||..||
  Rat   105 YPLQEEAKE------EDRLPAL-KKILSSGVFYFAWPND---------------GACFDLTIRAQ 147

  Fly   185 DRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPM--EGIMLKDWLLEVTHGFVS 247
            .:.:...:|.|                      .|.||..|..|:  ..:...||||:|..|.|:
  Rat   148 KQGDDCSEWGT----------------------SFFWNQLLHVPLRQHQVNCHDWLLKVICGVVT 190

  Fly   248 QSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSI 312
            ...:....:....||::|.|...||.|||.||.|..|.|:|.|||||.:.....:.:|.|:|||:
  Rat   191 IRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSV 255

  Fly   313 PSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYG----APLIMLNLVKKRERRKHESI 373
            |..|.|                 |..|..|.|   |..|.|    ||....::|..:|:...:.:
  Rat   256 PLFWEQ-----------------PGLQVGSHH---LRLHRGLEANAPAFERHMVLLKEQYGQQVV 300

  Fly   374 IS---------------KELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVME-------- 415
            ::               |:|.::..:...       ...|:||.   .:.:.|..:|
  Rat   301 VNLLGSRGGEEVLNRAFKKLLWASCHAGD-------TPMINFDF---HQFAKGRKLEKLENLLRP 355

  Fly   416 QLAIHAESIVQMTGMFFKAAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLG--- 477
            ||.:|.:..    |:|.|.....|..|.|.:|.||:|||||||:.|..|....|..|||.||
  Rat   356 QLKLHWDDF----GVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNS 416

  Fly   478 ------FVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQL------VHRIKTYRKTAPWGSQ 530
                  ||:|.|.            ::..:|..|:..:.||:.      |.::|
  Rat   417 KPITDRFVESFKA------------MWSLNGHGLSKVFTGSRALEGKAKVGKLK----------- 458

  Fly   531 GSDVMQTLSRYYSNTFSDTEKQHSINLFL--GIYKPSLTKQGPPIWELQTDYDMHNAFVPRADSK 593
              |..:::||...:.|.|..||.:|.|.|  .:|....|.:|..:                .|:.
  Rat   459 --DGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRML----------------LDNT 505

  Fly   594 AITDWVRHKVRACLPYSCADSNKLVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEISQL 658
            |:.....:|           .|.|         ||  |:|.                   :.:..
  Rat   506 ALLGLGSNK-----------QNSL---------SG--MLDG-------------------KATPR 529

  Fly   659 ALRYMPTFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNSS----SSSEGDDSSSDEELSA 719
            .|:.|...::.|:.|:|.               |.:.|:.|.|..    |:..|....:|..|.|
  Rat   530 ILKAMTERQSEFTNFKRI---------------QIAMGTWNVNGGKQFRSNLLGTTELTDWLLDA 579

  Fly   720 SFAEKEANQTESTEPAAATLATGLPSMEEIYGCTINPPSKQSMAVYKKYVQMGKLSSGGARPAQT 784
            .......:..:...| |...|.|...|.|:....|...|..:..::.:.:|
  Rat   580 PQLSGAVDSQDDGGP-ADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQ-------------- 629

  Fly   785 AVAQRDQELAKIMRGITLRPLSDYGTDSYLSVRPPVVP 822
                  :.:::..|.|.|......|...|:.|||..||
  Rat   630 ------KAISRSHRYILLTSAQLVGVCLYIFVRPYHVP 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	146/589 (25%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	86/354 (24%)
Synj2	NP_001106842.1	Syja_N	61..342	CDD:280532	86/357 (24%)
		EEP	547..878	CDD:294334	28/151 (19%)
		DUF1866	889..1025	CDD:286093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1393..1413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1442..1461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1468..1496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920