DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and RHD4

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_190714.2	Gene:	RHD4 / 824309	AraportID:	AT3G51460	Length:	597	Species:	Arabidopsis thaliana

Alignment Length:	576	Identity:	170/576 - (29%)
Similarity:	271/576 - (47%)	Gaps:	105/576 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TID--RLAHNRLSIEENANEF----------NSLEIRRFVASL--------SGS---PKVTSAYG 86
            |:|  ...|:||.:.|..:::          :.|:|.|..||:        |.|   ||:.|.:|
plant     3 TVDSRNKLHSRLRLWEFPDQYIIEPADGSGSSCLDISRVDASMKLIDQVPESNSVRVPKIRSIFG 67

  Fly    87 VLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVTSQRPPHPHEDR-----YKRM 146
            |:|.::.|.|.||::||:.:   .:|..|.:.|.....::|..........|.|.:     :.::
plant    68 VVGMLKLLAGSYLVVVTESE---RVGSFLGHPIFKVTTLKVLPCDHSLKNSPEEQKKMETEFSKL 129

  Fly   147 FQNIDLRSNFYFSYSYDLTRTLQ-YNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYA 210
            ....:..:..||||..:||.:.| .:|..          |..:.||.|.
plant   130 LSVAEKTTGLYFSYEVNLTLSSQRLHEMG----------DESKSLPLWR---------------- 168

  Fly   211 FRSDSRKRFVWNAYLLQPMEGIMLKDWLLEVTHGFVSQSCISIFGRH-VNVCLVARRSSRFAGTR 274
               .:..||:||.|:|:.:....|..:||.|..|..: |..:..||. |::.|:|||.:|..|||
plant   169 ---QAEPRFLWNNYMLEVLIDNKLDQFLLPVIQGSFN-SFETAIGRDIVDITLIARRCTRRNGTR 229

  Fly   275 FLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQ 339
            ..:|||:..|.|||.|||||||.......:|.|:|||:|..|.| :..:..||:.::...:...:
plant   230 MWRRGADLDGYVANFVETEQIVQMNGYTSSFVQVRGSMPFMWEQ-VVDLTYKPKFEIVQPEEAKR 293

  Fly   340 TPSLHFERLLFHYGAPLIMLNLVKKR--ERR---KHESIISKELEYSIRYLN-QFLPPPHRM-KH 397
            ....||..|...||: ::.::||.|:  |.|   |:.:::.......||||: .|    |:: .|
plant   294 IAERHFLDLRKKYGS-VLAVDLVNKQGGEGRLCEKYATVMQHITGDDIRYLHFDF----HQICGH 353

  Fly   398 IHFDMARQSRLSGGNVMEQLAIHAESIVQMTGMF-FKAAGSEPGLQTGIVRTNCVDCLDRTNSAQ 461
            |||:     |||  .:.||:    |..::..|.| ....|.:...|.|:||:||:|||||||..|
plant   354 IHFE-----RLS--ILYEQI----EGFLEKNGYFLLNEKGEKMKEQLGVVRSNCIDCLDRTNVTQ 407

  Fly   462 FAIGKCALGHQLERLGF-----VKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHR--IK 519
            ..||:..|..||:|:|.     ..|:.|.||..    .:.|:..|||.:::||.|:..:..  ::
plant   408 SMIGRKMLEVQLKRIGVFGAEETISSHLNFDEH----YKILWANHGDEISIQYSGTPALKGDFVR 468

  Fly   520 TYRKTAPWGSQG--SDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPI 573
            ...:||    .|  .|...:|.|||.|.|:|..||.:|:|..|.|..::::...|:
plant   469 YGHRTA----HGVLKDGWSSLRRYYLNNFADGTKQDAIDLLQGHYIVAVSRDMAPV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	170/576 (30%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	95/335 (28%)
RHD4	NP_190714.2	COG5329	65..551	CDD:227637	154/514 (30%)
RHD4	NP_190714.2	Syja_N	66..351	CDD:280532	91/323 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820