Protein Alignment FIG4 and sacm1lb

DIOPT Version :9

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_001074093.2
• Gene: sacm1lb / 791142
• ZFINID: ZDB-GENE-070112-542
• Length: 586
• Species: Danio rerio
• Alignment Length: 586
• Identity: 169/586 - (28%)
• Similarity: 267/586 - (45%)
• Gaps: 95/586 - (16%)

  Fly    13 LISSIQKVVLYETRARLYL------VGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRF 71
            :.|:.....|:.|..:.|:      ||             |.||.:|:|.|      .:|.:|:.
Zfish     1 MASTYNSFNLHTTAEKFYIEACDDGVG-------------DVLAIDRVSTE------MTLTVRKD 46

  Fly    72 VASLSGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVTSQRPP 136
            |..   |.......|::|.:|.:.|.||:::||:|....:..|.|:...|..::...:.......
Zfish    47 VPP---SAVTRPICGIMGTIRLVAGVYLIVITKKKKVGDLLGHAVWKASDFDIISYKKTVLHLTD 108

  Fly   137 HPHEDR--YKRMFQNIDLRSNFYFSYSYDLTRTLQ--YNESAPRYVGAKVDLDRDEPLPDWNTLT 197
            :..:|.  :..|..::.....|||:..||||.|||  .|.|                 |::..:|
Zfish   109 NQMQDNKVFLSMLNSVLNTDGFYFATDYDLTHTLQRLSNTS-----------------PEFQEMT 156

  Fly   198 SNVDKAHERVDYAFRSDSRKRFVWNAYLLQP-MEGIMLKDWLLEVTHGFVSQSCISIFGRHVNVC 261
                 ..||.|        :|||||.:||:. |....|..::..|.|||::.....|.|:..:..
Zfish   157 -----LLERAD--------QRFVWNGHLLREFMAQPELHRFVFPVIHGFIAMRSCCINGKIFDWN 208

  Fly   262 LVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDIS-KMVP 325
            |::|||...||.|:..||.:.:|..||.||||||:.......:|.|.|||||.:|||..: |..|
Zfish   209 LISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIIQYNGAKASFIQTRGSIPFYWSQRPNLKYKP 273

  Fly   326 KPQIQLDI--CDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKH-ESIISKELEYSIRYLNQ 387
            ||||...|  .|.:.:    ||:..:..||..:| ||||.::...|. |...:|    .:..|..
Zfish   274 KPQISKSINHLDGFQR----HFDSQIITYGKQVI-LNLVNQKGSEKPLEQAFAK----MVGSLGN 329

  Fly   388 FLPPPHRMKHIHFDMARQ-SRLSGGNVMEQLAIHAESIVQMTGMF----FKAAGSEPGLQTGIVR 447
            .:     :|:|.||..:: ||:.    ..:|.|..:::.::...|    ..:.||....|.|..|
Zfish   330 GM-----IKYIAFDFHKECSRMR----WHRLQILVDTVAELQDEFGYFLVDSDGSVQMQQDGTFR 385

  Fly   448 TNCVDCLDRTNSAQFAIGKCALGHQLERLGFVK-SAKLEFDSDCVTMLENLYEEHGDTLALQYGG 511
            :||:|||||||..|..:.:.:|..||||:..:. ..::|..:|...:.:|.:.::.:..|.||.|
Zfish   386 SNCMDCLDRTNVIQSLLARRSLQSQLERMAVLHVGQRIEEQADFEKIYKNAWADNANACAKQYAG 450

  Fly   512 SQLVHR--IKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIW 574
            :..:..  .:|.::| .||.. .|...::.|||.|.|||..:|.||:||||.|.........|:.
Zfish   451 TGALKTDFTRTGKRT-QWGLL-MDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYAVEEADMNTPLH 513

  Fly   575 E 575
            |
Zfish   514 E 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	168/580 (29%)
		Syja_N	85..407	CDD:280532	99/331 (30%)
sacm1lb	NP_001074093.2	COG5329	56..526	CDD:227637	153/509 (30%)
		Essential for phosphatidylinositol-4-phosphate phosphatase activity. /evidence=ECO:0000250|UniProtKB:Q9NTJ5	451..586		22/66 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820