Protein Alignment FIG4 and inpp5b

DIOPT Version :10

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: XP_009290335.3
• Gene: inpp5b / 563543
• ZFINID: ZDB-GENE-110411-228
• Length: 907
• Species: Danio rerio
• Alignment Length: 567
• Identity: 99/567 - (17%)
• Similarity: 179/567 - (31%)
• Gaps: 221/567 - (38%)

  Fly    63 FNSLEIRRFVASLSGSPK-------------VTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRH 114
            |..|::.:.....:.:||             ..:.|.::..|| |.|..||...|.:...||...
Zfish   288 FQELDLSKEAFLFNDTPKEPEWMLAVYKGLHPDAKYALVKLVR-LVGIMLLFYVKAEHAPHISEV 351

  Fly   115 LVYTIKDTVMVRVNE-----------------VTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSY 162
            ...|:...||.|:..                 |.|....|..|  ::|  :|.|.:
Zfish   352 EAETVGTGVMGRMGNKGAVSIRFQFHNSDICVVNSHLAAHTEE--FER--RNQDFK--------- 403

  Fly   163 DLTRTLQYNESAP---------------------RYVGAKVDLDRD-------EPLPDWNTLTSN 199
            |:.|.:|:.:..|                     |....:||..:|       |.|..::.|...
Zfish   404 DICRRIQFRQEDPTLPPLTILKHNIVLWLGDLNYRISDLEVDHVKDLISKKDFETLHTYDQLKRQ 468

  Fly   200 VDK-------AHERVDY--AFRSD--------SRK--------RFVWNAYLLQPM---EGIMLK- 235
            :|:       ....:|:  .::.|        |.|        |.:|....::.:   ..:.||
Zfish   469 MDEEVVFVGFTEGEIDFQPTYKYDTGSDQWDTSEKCRVPAWCDRILWRGKSIKQLHYQSHMTLKT 533

  Fly   236 ------DWLLEVTHGFVS--------QSCISIFGRHVNVCL----VARRSSRFAGTRFLKRGANF 282
                  ..|||:....|:        :..:....|..|.|:    ::.|...|...:|::
Zfish   534 SDHKPVSSLLEIGIKVVNEESYKRTFEEIVRQIDRLENDCIPSVSLSEREFHFQDVKFMQ----- 593

  Fly   283 QGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPY---------- 337
                 ::..|..:.:|||..|.|             :..:.:.:|.    .|.|:
Zfish   594 -----HQARTVTVHNDGQVPCQF-------------EFIQKLDEPA----YCKPWLTANPAKGFL 636

  Fly   338 AQTPSLHFERLLF--HYGAPLIMLNLVKKRERRKHESIISKELE----YSIRYLNQFLP------ 390
            ||..|:..:..:|  .:.||.:...|      ::.|.|:...||    |.|.....:||
Zfish   637 AQGASVDIDLEVFVNRHTAPELNAGL------QQLEDILVLHLERGKDYFISITGSYLPSCFGSS 695

  Fly   391 --------PPHRMKHIHFDMARQSRLSGGNVMEQLAIHAES---------------IVQMTGMFF 432
                    .|.:      ||..:|       :.:|::.:.|               |..|....|
Zfish   696 LSALCLLREPIQ------DMPLES-------IRELSVKSNSPVIDSADKPQEIPKEIWMMVDHLF 747

  Fly   433 KAAG------SEPGLQTGI--VRTNCVD--CLDRTNSAQFAIGKCAL 469
            :.|.      .:|||::..  :| :|:|  |||....:..::.:..|
Zfish   748 RYAKKQEDLFQQPGLRSEFEEIR-DCLDTGCLDTLPGSNHSVAEALL 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	Syja_N	85..407	CDD:460545	78/443 (18%)
inpp5b	XP_009290335.3	INPP5B_PH	1..143	CDD:465268
		INPP5c_INPP5B	253..545	CDD:197327	47/270 (17%)
		PapD-like	574..>648	CDD:373355	15/100 (15%)
		RhoGAP_OCRL1	680..892	CDD:239845	23/128 (18%)