DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and Synj

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	139/525 - (26%)
Similarity:	214/525 - (40%)	Gaps:	132/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KVTSAYGVLGFVRFLEG----YYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVT--SQRPPHP 138
            ||..|||.||.::...|    .:|:|||.   |..:|:     |.|..:.|:.:.|  |.:...|
  Fly    56 KVCDAYGCLGALQLNAGESTVLFLVLVTG---CVSMGK-----IGDIEIFRITQTTFVSLQNAAP 112

  Fly   139 HEDRYKRMFQNIDLRSNFYF-------------SYSYDLTRTLQYNESAPRYVGAKVDLDRDEPL 190
            :||:...:.:.:: ...|||             ||.:|:|...|..:.
  Fly   113 NEDKISEVRKLLN-SGTFYFAHTNASASASGASSYRFDITLCAQRRQQ----------------- 159

  Fly   191 PDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYL-LQPME-GIMLKDWLLEVTHGFVSQSCISI 253
                  |...|               .||.||..: :..|. ||..:.|||:...|.|....:.|
  Fly   160 ------TQETD---------------NRFFWNRMMHIHLMRFGIDCQSWLLQAMCGSVEVRTVYI 203

  Fly   254 FGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQ 318
            ..:.....:::|.|...|||||..||.|.:|.|||.|||||::.....:.::.|.|||:|..|.|
  Fly   204 GAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQ 268

  Fly   319 DISKMVPKPQIQLDICDPYAQTPSLHFERLL--FHYGAPLIMLNLVKKRERRKHESII------- 374
                    |.:|:          ..|..:|.  |...|.....::...|:|..:::::
  Fly   269 --------PGVQV----------GSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSL 315

  Fly   375 --SKELEYSIRYLNQFLPPPHRMK------HIHFDMARQSRLSGGNVMEQLAIHAESIVQM---T 428
              |||.|..:.  |:| ...|.|.      |:.||..::.|  ||| ...||...|.||..   .
  Fly   316 VGSKEGEAMLS--NEF-QRHHGMSAHKDVPHVVFDYHQECR--GGN-FSALAKLKERIVACGANY 374

  Fly   429 GMFFKAAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVTM 493
            |:|..:.|.....|.|:|||||:|||||||..|..:|...||.|||.|      |:......::.
  Fly   375 GVFHASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEAL------KMGGKQQNISR 433

  Fly   494 LENLYEE----HGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHS 554
            .|.::.:    :|:.::..|.|:..:.          .||:..|..::.:|...|...|..||.:
  Fly   434 FEEIFRQMWINNGNEVSKIYAGTGAIQ----------GGSKLMDGARSAARTIQNNLLDNSKQEA 488

  Fly   555 INLFL 559
            |::.|
  Fly   489 IDVLL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	139/525 (26%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	87/359 (24%)
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	87/359 (24%)
		INPP5c_Synj	538..863	CDD:197323
		DUF1866	862..1008	CDD:286093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850