DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and Fig4

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_001040561.1	Gene:	Fig4 / 309855	RGDID:	1311375	Length:	907	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	391/950 - (41%)
Similarity:	541/950 - (56%)	Gaps:	176/950 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PLISSIQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASL- 75
            |:|||:||:||||||||.:|||||:.||:||:|.|||.....|.:.::.:.:...|:|..:..|
  Rat     7 PIISSVQKLVLYETRARYFLVGSNHAETKFRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLD 71

  Fly    76 ------------SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV- 127
                        ||..:..||:||:||||||||||::|:|||:..|.||.|.:|.|:||.|:.:
  Rat    72 LGNRTKLSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIP 136

  Fly   128 NEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPD 192
            |:  |.|..||.|.||.|:|||:||.|||||||||||:.:||||.:..|.           ||..
  Rat   137 ND--SVRITHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRM-----------PLEM 188

  Fly   193 WNTLTSNVDKAHERVD---------------YAFRSDSRKRFVWNAYLLQPMEGIMLKDWLLEVT 242
            ..:.||..  ..|..|               :...|:...::|||..||..::..:.:||||.:.
  Rat   189 LKSETSKT--CQESFDIFEDEGLTTQGGSGVFGISSEPYMKYVWNGELLDIIKNSVHRDWLLYII 251

  Fly   243 HGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFT- 306
            |||..||.:.|:||.|.|.|:||||||||||||||||||.:||||||||||||:.|.. :.:||
  Rat   252 HGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDAS-VMSFTA 315

  Fly   307 -------QMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKK 364
                   |:|||:|..||||||.|:|||.|.||..||:|...:|||:::|..:|:|:|:|||||:
  Rat   316 GSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKE 380

  Fly   365 RERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMTG 429
            ||:||||.|:|:||..::.||||||||.|.:.:|.:|||:.::....||:::|.:.|||:|:.||
  Rat   381 REKRKHERILSEELVAAVTYLNQFLPPEHSIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTG 445

  Fly   430 MFFKAAGS------------EPG--------LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLE 474
            .|.....|            |.|        |||||:||||||||||||:|||.:|||||.:||.
  Rat   446 FFVNRPDSYCSVLRPDEKWNELGGRVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLY 510

  Fly   475 RLGFVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLS 539
            .||.:....|:||:|.|.:.|.|||:|||||:|||||||||||:|||||.|||.....|:|||||
  Rat   511 SLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLS 575

  Fly   540 RYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHN----AFVPRADSKAITDW-- 598
            |||||.|||.::|.|||||||::.|  |:..|.:|||.||:.:|:    :.:|  ..::.|.|
  Rat   576 RYYSNAFSDADRQDSINLFLGVFHP--TEGKPHLWELPTDFYLHHKNTMSLLP--PKRSYTHWWT 636

  Fly   599 ---VRHKVRACLPYS---CADSNK--LVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEI 655
               |:|   ..|||.   ||.:.|  .||:..|..    |.||.::.:.:.::.:.|.:.....:
  Rat   637 PEVVKH---LPLPYDEVICAANLKKLTVKKFHRWE----EEIDIHNEFFRPYELSSFDDTFCLAM 694

  Fly   656 SQLALRYMP-TFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNS----------------- 702
            :..|..:|| |...:.|||     |.||    |..||:|..|:.::..
  Rat   695 TSSARDFMPKTIGIDPSPF-----TVRK----PDETGKSVLGNKSNREEAVLQRKTAASAPPPPS 750

  Fly   703 ----SSSSEGDDSSSDEELSASFAEKE--ANQTESTEPAAATLATGLPSMEEIYGCTINPP-SKQ 760
                ||||| |||.:|.|...|.:::.  ...|::.:.|..|.:...| |:|:||.:::.. |::
  Rat   751 EEAVSSSSE-DDSGTDREDEGSISQRSTPVKMTDTGDSAKVTESVAQP-MKEVYGVSLSRSLSEE 813

  Fly   761 SMAVYKKYVQMGKLSSGGARPAQTAVAQRDQE------LAKIMRG-ITLRPLSDYGTDSYLSVRP 818
            ..::|.::||:|:             :|..|:      .|:...| |.|.|:|.:..|:...|:|
  Rat   814 DHSIYARFVQLGQ-------------SQHRQDWSSPQMCARCSDGVIKLTPISAFSQDNIYEVQP 865

  Fly   819 PVVPRKS----------------------LTIYAEYCRTR 836
            |.|.|||                      ..||.||.|.|
  Rat   866 PRVDRKSTEIFQAHIQASQGIMQPLGKEDTAIYREYIRNR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	310/645 (48%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	171/345 (50%)
Fig4	NP_001040561.1	COG5329	14..636	CDD:227637	310/641 (48%)
Fig4	NP_001040561.1	Syja_N	93..423	CDD:280532	171/345 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340847
Domainoid	1	1.000	312	1.000	Domainoid score	I1271
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6713
Inparanoid	1	1.050	623	1.000	Inparanoid score	I835
OMA	1	1.010	-	-		QHG58176
OrthoDB	1	1.010	-	-		D219218at33208
OrthoFinder	1	1.000	-	-		FOG0002534
OrthoInspector	1	1.000	-	-		oto97476
orthoMCL	1	0.900	-	-		OOG6_101803
Panther	1	1.100	-	-	LDO	PTHR45738
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1658
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770