Protein Alignment FIG4 and SACM1L

DIOPT Version :9

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_001306000.1
• Gene: SACM1L / 22908
• HGNCID: 17059
• Length: 609
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 167/608 - (27%)
• Similarity: 274/608 - (45%)
• Gaps: 116/608 - (19%)

  Fly    15 SSIQKVVLYETRARLYLV----GSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASL 75
            ::.:::.|:.|..:.|:.    |:::      :||||     |:|.|.      :|.:::.|..
Human     4 AAYEQLKLHITPEKFYVEACDDGADD------VLTID-----RVSTEV------TLAVKKDVPP- 50

  Fly    76 SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKD-------TVMVRVNEVTSQ 133
              |......:|:||.:..:.|.||:::||:........|:|:...|       ..|:.:.::..|
Human    51 --SAVTRPIFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQ 113

  Fly   134 RPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTS 198
                 ....:..|..::.....||||.:||||.|||                          ..|
Human   114 -----DNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQ--------------------------RLS 147

  Fly   199 NVDKAHERVDYAFRSDSRKRFVWNAYLLQPMEG-IMLKDWLLEVTHGFVSQSCISIFGRHVNVCL 262
            |.....:.:....|:|  :|||||.:||:.:.. ..:..:.|.|.|||::....||.|::.:..|
Human   148 NTSPEFQEMSLLERAD--QRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWIL 210

  Fly   263 VARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDIS-KMVPK 326
            ::|||...||.|:..||.:.:|..||.|||||||.......:|.|.|||||..|||..: |..|.
Human   211 ISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPL 275

  Fly   327 PQIQ--LDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFL 389
            |||.  .:..|.:.:    ||:..:..||..:| :||:.::..       .|.||.:...:...|
Human   276 PQISKVANHMDGFQR----HFDSQVIIYGKQVI-INLINQKGS-------EKPLEQTFATMVSSL 328

  Fly   390 PPPHRMKHIHFDMARQSRLSGGNV-MEQLAIHAESIVQM----TGMFFKAAGSEPGLQTGIVRTN 449
             ....|::|.||..::.:    |: .::|:|..:.:.:|    :.....:||.....|.|:.|:|
Human   329 -GSGMMRYIAFDFHKECK----NMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSN 388

  Fly   450 CVDCLDRTNSAQFAIGKCALGHQLERLGFVK-SAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQ 513
            |:|||||||..|..:.:.:|..||:|||.:. ..|||...:...:.:|.:.::.:..|.||.|:
Human   389 CMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGT- 452

  Fly   514 LVHRIKT-YRKTAPWGSQG--SDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWE 575
              ..:|| :.:|......|  .|...::.|||.|.|||..:|.||:||||.|.....:...|:
Human   453 --GALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPL-- 513

  Fly   576 LQTDYDMHNAFVPRADSKAITDW 598
                      .|||       ||
Human   514 ----------SVPR-------DW 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	167/604 (28%)
		Syja_N	85..407	CDD:280532	94/332 (28%)
SACM1L	NP_001306000.1	COG5329	57..513	CDD:227637	147/508 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820