Protein Alignment FIG4 and INPP5F

DIOPT Version :10

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_001427929.1
• Gene: INPP5F / 22876
• HGNCID: 17054
• Length: 1139
• Species: Homo sapiens
• Alignment Length: 998
• Identity: 200/998 - (20%)
• Similarity: 342/998 - (34%)
• Gaps: 356/998 - (35%)

  Fly    86 GVLGFVRFLEG--YYLLLVTKRKCCAHI-GRHLVYTIKDTVMVRVNEVTSQ-------------- 133
            ||:|.::....  ::|:|:.::.....: |.|.|..:....::.::|:..|
Human    50 GVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGI 114

  Fly   134 -RP----PHPHEDRY------------------------------KRMFQNI-----DLRSNFYF 158
             :|    |.|.:.::                              :|:.:.:     |..| ||:
Human   115 NKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSES-FYY 178

  Fly   159 SYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNA 223
            |.:||||.::|...:..|           :..|.|           ::||        .||.||.
Human   179 SLTYDLTNSVQRQSTGER-----------DGRPLW-----------QKVD--------DRFFWNK 213

  Fly   224 YLLQPMEGIMLKD---WLLEVTHGFV-------------------------SQSCISIFGRHVNV 260
            |::|.:..|...|   |::.:..|||                         ..:|:........|
Human   214 YMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLV 278

  Fly   261 CLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVP 325
            .|::|||...||.|:.:||.:..|:|||.|||||::.......:|.|.|||:|..|||...:..|
Human   279 ALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNP 343

  Fly   326 KPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFL- 389
            :|::.....:..|.. ..|||..|..|...:| :|||.:..|   |.||..      .||.|.|
Human   344 RPRLDRSEKETVAYF-CAHFEEQLNIYKKQVI-INLVDQAGR---EKIIGD------AYLKQVLL 397

  Fly   390 -PPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESI-----------VQMTGMFFKAAGSEPGLQ 442
             ...| :.::.||.....|   |...|.:....::|           |...|:..|        |
Human   398 FNNSH-LTYVSFDFHEHCR---GMKFENVQTLTDAIYDIILDMKWCWVDEAGVICK--------Q 450

  Fly   443 TGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLAL 507
            .||.|.||:|||||||..|.||.:..:..||::|| |...:......|..:.:.::..:||:::.
Human   451 EGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLG-VMPPEQPLPVKCNRIYQIMWANNGDSISR 514

  Fly   508 QYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSL-TKQGP 571
            ||.|:..:....|............|.:.:.:|||.|.|.|..:|..|:    |...:| ..||.
Human   515 QYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVID----INNSTLDLMQGI 575

  Fly   572 PIWELQTDYDMHNAFV------------PRADSKAITDWVRHKVRACLP---------------- 608
            |:.|     |:::.|.            .|:..:.|:..::..::..||
Human   576 PVTE-----DLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDP 635

  Fly   609 ------------------------------------------------------------YSC-- 611
                                                                        :||
Human   636 SLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMR 700

  Fly   612 --------------------------ADSNKLVKELFRV----HSSGLEMID------------- 633
                                      .|:.:.:.|:.::    ..|.|.:|:
Human   701 LHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHED 765

  Fly   634 ---------------------AYSNYHQSFKWTDFSEHIAFEISQLALRYMPTFRTNFSPFQRQI 677
                                 .:|:.:|..|.|..:.:|. .:.:|.....|..:.||      :
Human   766 IIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIG-NLRKLGNFTKPEMKVNF------L 823

  Fly   678 QTSRKA---RQNPSMTGQSSTGSMN-----SNSSSSSEGDDSSSDEELSASFAEKE---ANQTES 731
            :.:.|.   :.:.|:....:||.|:     |:...||:.|...|||.|:.|.::::   ||..||
Human   824 KPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLES 888

  Fly   732 TEPAAATL--------ATGLPSMEEIYGCT---INPPSKQSMAVYKKYVQMGKLSSGGARPAQTA 785
            ..|....|        |..|.|..:....|   ::.||:.::|      ....|..|...|.:.:
Human   889 VGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVA------HGSGLGKGQESPLKKS 947

  Fly   786 VAQRDQELAKIMRGITLRPLSDY 808
            .:..|   ..|:.|.. :|:..|
Human   948 PSAGD---VHILTGFA-KPMDIY 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	Syja_N	85..407	CDD:460545	93/407 (23%)
INPP5F	NP_001427929.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..882		9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..949		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1024