DRSC/TRiP Functional Genomics Resources

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Protein Alignment FIG4 and INPP5F

DIOPT Version :9

Sequence 1:NP_608841.1 Gene:FIG4 / 33658 FlyBaseID:FBgn0031611 Length:858 Species:Drosophila melanogaster
Sequence 2:NP_055752.1 Gene:INPP5F / 22876 HGNCID:17054 Length:1132 Species:Homo sapiens


Alignment Length:997 Identity:199/997 - (19%)
Similarity:340/997 - (34%) Gaps:361/997 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 GVLGFVRFLEG--YYLLLVTKRKCCAHI-GRHLVYTIKDTVMVRVNEVTSQ-------------- 133
            ||:|.::....  ::|:|:.::.....: |.|.|..:....::.::|:..|              
Human    50 GVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGI 114

  Fly   134 -RP----PHPHEDRY------------------------------KRMFQNI-----DLRSNFYF 158
             :|    |.|.:.::                              :|:.:.:     |..| ||:
Human   115 NKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSES-FYY 178

  Fly   159 SYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNA 223
            |.:||||.::|...:..|           :..|.|           ::||        .||.||.
Human   179 SLTYDLTNSVQRQSTGER-----------DGRPLW-----------QKVD--------DRFFWNK 213

  Fly   224 YLLQPMEGIMLKD---WLLEVTHGFV-------------------------SQSCISIFGRHVNV 260
            |::|.:..|...|   |::.:..|||                         ..:|:........|
Human   214 YMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLV 278

  Fly   261 CLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVP 325
            .|::|||...||.|:.:||.:..|:|||.|||||::.......:|.|.|||:|..|||...:..|
Human   279 ALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNP 343

  Fly   326 KPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFL- 389
            :|::.....:..|.. ..|||..|..|...:| :|||.:..|   |.||..      .||.|.| 
Human   344 RPRLDRSEKETVAYF-CAHFEEQLNIYKKQVI-INLVDQAGR---EKIIGD------AYLKQVLL 397

  Fly   390 -PPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESI-----------VQMTGMFFKAAGSEPGLQ 442
             ...| :.::.||.....|   |...|.:....::|           |...|:..|        |
Human   398 FNNSH-LTYVSFDFHEHCR---GMKFENVQTLTDAIYDIILDMKWCWVDEAGVICK--------Q 450

  Fly   443 TGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLAL 507
            .||.|.||:|||||||..|.||.:..:..||::|| |...:......|..:.:.::..:||:::.
Human   451 EGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLG-VMPPEQPLPVKCNRIYQIMWANNGDSISR 514

  Fly   508 QYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPP 572
            ||.|:..:....|............|.:.:.:|||.|.|.|..:|..|:|.          ||.|
Human   515 QYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLM----------QGIP 569

  Fly   573 IWELQTDYDMHNAFV------------PRADSKAITDWVRHKVRACLP----------------- 608
            :.|     |:::.|.            .|:..:.|:..::..::..||                 
Human   570 VTE-----DLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPS 629

  Fly   609 -----------------------------------------------------------YSC--- 611
                                                                       :||   
Human   630 LIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRL 694

  Fly   612 -------------------------ADSNKLVKELFRV----HSSGLEMID-------------- 633
                                     .|:.:.:.|:.::    ..|.|.:|:              
Human   695 HYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDI 759

  Fly   634 --------------------AYSNYHQSFKWTDFSEHIAFEISQLALRYMPTFRTNFSPFQRQIQ 678
                                .:|:.:|..|.|..:.:|. .:.:|.....|..:.||      ::
Human   760 IGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIG-NLRKLGNFTKPEMKVNF------LK 817

  Fly   679 TSRKA---RQNPSMTGQSSTGSMN-----SNSSSSSEGDDSSSDEELSASFAEKE---ANQTEST 732
            .:.|.   :.:.|:....:||.|:     |:...||:.|...|||.|:.|.::::   ||..||.
Human   818 PNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESV 882

  Fly   733 EPAAATL--------ATGLPSMEEIYGCT---INPPSKQSMAVYKKYVQMGKLSSGGARPAQTAV 786
            .|....|        |..|.|..:....|   ::.||:.::|      ....|..|...|.:.:.
Human   883 GPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVA------HGSGLGKGQESPLKKSP 941

  Fly   787 AQRDQELAKIMRGITLRPLSDY 808
            :..|   ..|:.|.. :|:..|
Human   942 SAGD---VHILTGFA-KPMDIY 959

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FIG4NP_608841.1 COG5329 19..599 CDD:227637 146/622 (23%)
Syja_N 85..407 CDD:280532 93/407 (23%)
INPP5FNP_055752.1 Syja_N 50..415 CDD:280532 93/407 (23%)
hSac2 595..697 CDD:289241 5/101 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 846..875 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..942 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 974..1017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D359616at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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