Protein Alignment FIG4 and unc-26

DIOPT Version :10

• Sequence 1: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_001023266.1
• Gene: unc-26 / 178284
• WormBaseID: WBGene00006763
• Length: 1119
• Species: Caenorhabditis elegans
• Alignment Length: 779
• Identity: 194/779 - (24%)
• Similarity: 294/779 - (37%)
• Gaps: 235/779 - (30%)

  Fly    80 KVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVTSQRPPHPHEDRYK 144
            |:..|||:||         :|.:||               .:.|:|.|..|.|....: ..|..|
 Worm    55 KIVDAYGILG---------VLAITK---------------DEAVLVAVTGVLSVGQLY-GADILK 94

  Fly   145 ---------RMF---QNIDLR----------SNFYFS--YSYDLTRTLQYNESAPRYVGAKVDLD 185
                     |.|   :|:|.|          ..||||  .||||||:.|:.:|
 Worm    95 ITNVEFISLRTFGSVENVDSRIIDLQRLLSSQMFYFSSLQSYDLTRSAQHRDS------------ 147

  Fly   186 RDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPME--GIMLKDWLLEVTHGFVSQ 248
                              |:..|        .||.||..|....:  ||...:|||:...|.|..
 Worm   148 ------------------HDCSD--------ARFFWNRSLHFSFQRYGIDTDNWLLKCMAGSVLV 186

  Fly   249 SCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIP 313
            ..:.:......|.|::|.|....||||..||||:.|:|||.|||||::...::.|:..|:|||||
 Worm   187 RVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLLLFDEKECSLLQIRGSIP 251

  Fly   314 SHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKEL 378
            ..|.|. ...|...:::|...:........|..:|...|| ...::||:.::|..
 Worm   252 LFWEQP-GVNVGSHKVKLRAFETSLPAYHRHLSQLQHRYG-EFAIVNLLGRKEGE---------- 304

  Fly   379 EYSIRYLNQFLPPPHRMKH-------IHFDMARQSRLSGGNVMEQLAIHAESIVQMT-------- 428
                |.|.......|:..|       |.||...|.::|           .|:|||:.
 Worm   305 ----RVLGDAFKTQHKSSHFAPLVDFIDFDYHAQMKIS-----------KEAIVQLKKKMSPHMT 354

  Fly   429 --GMFFKAAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGF--VKSAKLEFDSD 489
              |.|:.........|||::||||:|||||||:.|.||| ..:.|  :::.|  :.:.|:..:..
 Worm   355 KHGFFYSMGKEIVKRQTGVIRTNCLDCLDRTNAVQTAIG-LQMSH--DQVAFLNLNAGKVNVEQR 416

  Fly   490 CVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHS 554
            ...:|.:|::::||..:..|.|:..:          ...|:..|..::|:|...|...|..||.|
 Worm   417 VEEILRDLWQKNGDQCSTIYAGTGAL----------DGKSKLKDASRSLARTIQNNLMDGAKQES 471

  Fly   555 INLFL--GIYKPSLTKQGPPIWELQTDYDMHNAFVPRADSKAITDWVRHKVRAC--LPYSCADSN 615
            .:|||  ..|.|.|             :|                      |||  ||.|
 Worm   472 FDLFLTGAAYDPRL-------------FD----------------------RACNILPPS----- 496

  Fly   616 KLVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEISQLALRYMPTFRTNFSPFQRQIQTS 680
             |::|.:..|    |..||.|...:  :..:.:|..:.:|      ::.|:..|          .
 Worm   497 -LIQESYYYH----EYADAVSQLVE--RSPEIAEPQSIKI------FVGTWNVN----------G 538

  Fly   681 RKARQNPSMTGQSSTGS---MNSNSSSSSEGDDSSSD------EE---LSASFAEKEA--NQTES 731
            .|...|.:...:||...   .||.:...|..|:..:|      ||   |:||...|.:  ||...
 Worm   539 GKNIHNVAFRNESSLSHWIFANSMTRLVSVEDEQLADIVAIGVEELVDLNASNMVKASTTNQRMW 603

  Fly   732 TEPAAATLATGLP----SMEEIYGCTINPPSKQSMAVYKK--YVQMGKLSSGGARPAQTAVAQR 789
            .|....||:...|    ..|::.|..:...::..::.|.|  .|...|...|||...:.:||.|
 Worm   604 CESIRKTLSEKAPFVLIGSEQLVGVCLFLFARPRVSPYLKDFAVASVKTGMGGATGNKGSVAFR 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	Syja_N	85..407	CDD:460545	92/354 (26%)
unc-26	NP_001023266.1	COG5329	50..484	CDD:227637	141/531 (27%)
		INPP5c_Synj	527..835	CDD:197323	36/157 (23%)
		RRM_SF	850..978	CDD:473069