DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and sac-2

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_001252206.1	Gene:	sac-2 / 173236	WormBaseID:	WBGene00012353	Length:	783	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	200/909 - (22%)
Similarity:	335/909 - (36%)	Gaps:	222/909 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASLSGSPKVTSA 84
            :::|.|...|.|.....|      :..||.....|...|     .||||......|.|:.:.
Worm     1 MIIYTTPTALILEEQGER------VEFDRRNGKVLEKPE-----ESLEILDQDVVLCGNVEF--- 51

  Fly    85 YGVLGFVRFLEGYYLLLVTKRKCCAHI------GRHLVYTIKDTVMVRV---------------- 127
              ::|.:.|.|.::|..|......|..      ..|.:..|:..:.:.|
Worm    52 --LIGKISFDEQHFLFFVVDSSVVACYRGTSAESSHSIRRIERVIAINVKSDGSVIKSQITPGSG 114

  Fly   128 ---------------NEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRY 177
                           .:||...|.....|...::|.:   ..:|||..|.|:|      .|:.:|
Worm   115 TKLKQGTEKIMKFFAEKVTKAEPRPALLDDVLKLFND---SKDFYFCRSRDVT------ISSQKY 170

  Fly   178 VGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPMEGIMLKD-WLLEV 241
            ...:                    :||         .|...|.||..::..:....:.| :...:
Worm   171 FEKR--------------------EAH---------TSEDSFFWNKRMVGNLGEAKISDKFTCPI 206

  Fly   242 THGFVSQSCISI---FGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRIC 303
            ..|:|:.|.:.|   ...::.:.:::|||:|.||.|:|:||.:...:|||.||||.|::..:...
Worm   207 MQGYVATSQLEITDQINAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHEL 271

  Fly   304 AFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERR 368
            :|.|.|||||..|||...|..|...|...:.:.:..... ||:||..||..||:.::||.:|.|
Worm   272 SFVQCRGSIPVFWSQRGFKYRPPLIINRSVEETHGVFTE-HFKRLKAHYDTPLVAVSLVDQRGR- 334

  Fly   369 KHESIISKELEYSIRYLNQFLPPPHRMK-------HIHFDMARQSRLSGGNVMEQLAIHAESIVQ 426
                    ||..:.|:|.      |.:|       ...||:.:..|......::.|....|..::
Worm   335 --------ELPLAQRFLE------HCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLK 385

  Fly   427 MTGM-FFKAAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDC 490
            ..|. :....|.....|.|:|||||:|||||||..|..|....:..|.:|||.       |...|
Worm   386 TIGFCWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGI-------FGPLC 443

  Fly   491 ------VTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDT 549
                  |..::.::.::||.::.||.|:..:....|............|...:.||||.....|.
Worm   444 EPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDA 508

  Fly   550 EKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHNAFVPRADSKAITDWVRHKVRACLP------ 608
            ::|.:||:..|              :.:.|.:.......:.:.:.|:..|...::..:|
Worm   509 QRQKAINIVTG--------------QTEADENAEEEENEKEEEENISRMVTETIQFLVPTQQTVI 559

  Fly   609 --------YSCADSNKLVKELFRVHSSGLEMIDAYSNYH-QSFKWTDFSEHIAFEISQLALRYMP 664
                    :..:|....|..|.|   |.|.::    .|. ...|.||        :..:||..:.
Worm   560 AGWGLINAFQSSDEIDTVVILTR---SNLYIV----TYEIDGEKMTD--------VQIVALEDIN 609

  Fly   665 TFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNSS----SSSEGDD--SSSDEELSASFAE 723
            |.:|..|...|  |.:|..........:.||..:.:|::    |..|.::  ||..|::...
Worm   610 TIQTGTSGNNR--QCARLETLEGVFIWRPSTVRLFNNTAIRLKSLEEANEYISSVAEQIQVG--- 669

  Fly   724 KEANQTESTEPAAATLA-TGLPSMEEIYGCTINPPSKQSM-AVYKKYVQMGKLSSGGARPAQTAV 786
              .|.....|.:...:| ..:|.|      :::..|..:| |::.|..::||.||.....:..:.
Worm   670 --RNMLTGAEGSVVPVAKITIPQM------SVHRKSMAAMGALFGKIKRVGKPSSLSKSASTIST 726

  Fly   787 AQ--------------RDQELAKIMRGITLRPLSDYGTDSYLSVRPPVVPRKSLTIYAEYCRTR 836
            ||              .|..:.||::      :|.:.:||     |...|..||......|:|:
Worm   727 AQLPETDGNESDASQKSDHLMTKILK------MSQFKSDS-----PQPEPFSSLLPAISECQTK 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	145/633 (23%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	84/369 (23%)
sac-2	NP_001252206.1	COG5329	25..520	CDD:227637	136/579 (23%)
sac-2	NP_001252206.1	hSac2	549..>615	CDD:372122	15/80 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920