DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and figo-1

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_492266.2	Gene:	figo-1 / 172620	WormBaseID:	WBGene00007912	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	945	Identity:	309/945 - (32%)
Similarity:	478/945 - (50%)	Gaps:	205/945 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASLSGSPKV 81
            ::|:.:|||::|.|::|.::..:|:.:|.|||:....|...|...::...||...:|::|....|
Worm     5 LRKITVYETKSRFYIIGCDSTGSRYNVLKIDRIDPKALITGEPEYDYTREEILELLATISDGSSV 69

  Fly    82 ------------------TSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV- 127
                              |:|:|:||.|||:|||||:::|:....|.:|.|.||.|.:..|:.:
Worm    70 VYRSSSKKGTKSGLIERATNAFGILGCVRFVEGYYLIIITRAHAVATLGYHPVYKIVEVAMIPIA 134

  Fly   128 -NEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLP 191
             :.|::.    ..|.:|.::||::||.::||||||||::||.|.|...                .
Worm   135 MDGVSTS----SEEQKYVKLFQSVDLSTDFYFSYSYDMSRTFQENSLR----------------S 179

  Fly   192 DWNTLTSNVDKAH-ERVDYAFRSDSRKRFVWNAYLLQPM-EGIMLKDWLLEVTHGFVSQSCISI- 253
            |||.        | :|     |.::.:|||||::||:|: :.::.:.|.:|:.||:|.|..|.:
Worm   180 DWNN--------HGQR-----RLEADERFVWNSFLLEPLRKNLISERWFVEIVHGYVRQEYIFLP 231

  Fly   254 FGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQI---------VSDGQRICAFTQMR 309
            .|| :::.::.|||:::|||||||||||..|:|||.||||||         |:|| |..:|.|||
Worm   232 IGR-ISLTIIGRRSTKYAGTRFLKRGANPTGNVANYVETEQIVWDMASSGNVADG-RFSSFVQMR 294

  Fly   310 GSIPSHWSQDISK--MVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHES 372
            ||:|..||||.|.  :|.||.|.:|..:|:|||.:.||..:...||.|::::||:|:.|:|:||.
Worm   295 GSVPMRWSQDPSTRGVVGKPLILIDNHEPHAQTAASHFRDVRNKYGNPIVIMNLIKRNEKRRHEG 359

  Fly   373 IISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGG-------NVMEQLAIHAESIVQMTGM 430
            ::..:...:|.|||||||...::.:|.||:||.::.:..       ||||.|::  :||:: .|.
Worm   360 VLHTQFLKNIEYLNQFLPNEEKLCYISFDVARCNKAANSMPSINVLNVMEDLSM--KSILK-NGW 421

  Fly   431 F-------------------FKAAGSEPG---LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQL 473
            |                   ..|..|:.|   :|.||.||||||||||||.|||.|.|.|||.||
Worm   422 FQSFPLSEALKIRPREAFATLDAHHSKDGRFMIQHGICRTNCVDCLDRTNVAQFVIAKVALGCQL 486

  Fly   474 ERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTL 538
            ..:|.:....|...|:...:||::::|||||:||||.||||||.||||:|||.:..:..||.|||
Worm   487 CAMGILDEPNLTLQSEVCRLLEDMFDEHGDTMALQYAGSQLVHSIKTYKKTAAFQERRRDVFQTL 551

  Fly   539 SRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHNAFVPRADS---------KA 594
            ||||||||:|.:||.:||||||:::|.:|.. ..:|:|.:||::|..:..:.::         |.
Worm   552 SRYYSNTFNDWDKQMAINLFLGVFRPRITTM-KNLWDLTSDYNLHFPYSLKINTDYCAWTLSEKE 615

  Fly   595 ITDWVRHKVRACLPYSCADSNKLVKELFRVHSSG-------------LEMIDAYSNYHQSFKWTD 646
            :.|.|      .|.|..::::....|:..:...|             ....:.:.:||:::::|.
Worm   616 LEDLV------FLDYDESENSDGYVEIRSIDVDGRRGSEGSEYRTLLFSSHEDFRDYHRTYEFTS 674

  Fly   647 FSEHIA--FEISQLALRY-----MPTFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNSSS 704
            ..:.|.  |.|...|::.     .||....|....:..:|..|.::.|           |.....
Worm   675 LDDRIGRLFSIENRAIQVDGINEEPTTHAQFLKLWKTTETKEKDQKKP-----------NKKDKE 728

  Fly   705 SSEGDDSSSDEELSASFA-----------------------EKEANQTESTEP------AAATLA 740
            ..|.||...|||:|..::                       :|...:.|||.|      ..:.|:
Worm   729 EKESDDEDDDEEISTQWSDVVEAQQEWYDLVNAPGNVTTTLQKSPTKRESTPPRNTSRAKRSLLS 793

  Fly   741 TGLPSMEEIYGCTINPPSKQSMAVYKKYVQMGKLSSGGARPAQTAVA--QRDQELAKIMRGITLR 803
            |||...::||.........:....|:||             |.||..  .||.|..|    .||
Worm   794 TGLQFAKDIYHLDHLKTQPEERRYYEKY-------------AITAFKCNVRDWEKVK----PTL- 840

  Fly   804 PLSDYGTDSYLSVRPPVVPRKSLTIYAEYC-RTRS 837
             ||::      .:...|.||:......:.| ||.|
Worm   841 -LSEF------KITSEVEPRRPTFFTTDDCYRTES 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	251/651 (39%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	135/337 (40%)
figo-1	NP_492266.2	Syja_N	91..394	CDD:367065	135/337 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159345
Domainoid	1	1.000	239	1.000	Domainoid score	I1272
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I937
Isobase	1	0.950	-	0	Normalized mean entropy	S1362
OMA	1	1.010	-	-		QHG58176
OrthoDB	1	1.010	-	-		D219218at33208
OrthoFinder	1	1.000	-	-		FOG0002534
OrthoInspector	1	1.000	-	-		oto18561
orthoMCL	1	0.900	-	-		OOG6_101803
Panther	1	1.100	-	-	LDO	PTHR45738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R444
SonicParanoid	1	1.000	-	-		X1658
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750