DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and Fig4

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_598760.1	Gene:	Fig4 / 103199	MGIID:	2143585	Length:	907	Species:	Mus musculus

Alignment Length:	947	Identity:	395/947 - (41%)
Similarity:	545/947 - (57%)	Gaps:	170/947 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PLISSIQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASL- 75
            |:|||:||:||||||||.:|||||:.||::|:|.|||.....|.:.::.:.:...|:|..:..|
Mouse     7 PIISSVQKLVLYETRARYFLVGSNHAETKYRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLD 71

  Fly    76 ------------SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV- 127
                        ||..:..||:||:||||||||||::|:|||:..|.||.|.:|.|:||.|:.:
Mouse    72 LGNRTKMSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIP 136

  Fly   128 NEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPD 192
            |:  |.|..||.|.||.|:|||:||.|||||||||||:.:||||.:..|.           ||
Mouse   137 ND--SVRISHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRM-----------PL-- 186

  Fly   193 WNTLTSNVDKA-HERVD---------------YAFRSDSRKRFVWNAYLLQPMEGIMLKDWLLEV 241
             ..|.|...|| .|..|               :...|:...::|||..||..::..:.:||||.:
Mouse   187 -EMLKSETSKACQESFDIFEDEGLITQGGSGVFGISSEPYMKYVWNGELLDIIKNTVHRDWLLYI 250

  Fly   242 THGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFT 306
            .|||..||.:.|:||.|.|.|:||||||||||||||||||.:||||||||||||:.|.. :.:||
Mouse   251 IHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDAS-VMSFT 314

  Fly   307 --------QMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVK 363
                    |:|||:|..||||||.|:|||.|.||..||:|...:|||:::|..:|:|:|:|||||
Mouse   315 AGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHVAALHFDQMLQRFGSPIIILNLVK 379

  Fly   364 KRERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMT 428
            :||:||||.|:|:||..::.||||||||.|.:.:|.:|||:.::....||:::|.:.|||:|:.|
Mouse   380 EREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKT 444

  Fly   429 GMFFKAAGS------------EPG--------LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQL 473
            |.|.....|            |.|        |||||:||||||||||||:|||.:|||||.:||
Mouse   445 GFFVNRPDSYCSILRPDEKWNELGGHVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQL 509

  Fly   474 ERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTL 538
            ..||.:....|:||:|.|.:.|.|||:|||||:|||||||||||:|||||.|||.....|:||||
Mouse   510 YSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTL 574

  Fly   539 SRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMH-----NAFVPRADSKAITDW 598
            ||||||.|||.::|.|||||||::.|  |:..|.:|||.||:.:|     :...||   ::.|.|
Mouse   575 SRYYSNAFSDADRQDSINLFLGVFHP--TEGKPHLWELPTDFYLHHKNTMSLLPPR---RSYTYW 634

  Fly   599 -----VRHKVRACLPYS---CADSNK--LVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAF 653
                 |:|   ..|||.   ||.:.|  :||:..|..    |.||.::.:.:.::.:.|.:....
Mouse   635 WTPEVVKH---LPLPYDEVICAANLKKLMVKKFHRWE----EEIDIHNEFFRPYELSSFDDTFCL 692

  Fly   654 EISQLALRYMP-TFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNS--------------- 702
            .::..|..:|| |...:.|||     |.||    |..||:|..|:.|:..
Mouse   693 AMTSSARDFMPKTVGIDPSPF-----TVRK----PDETGKSVLGNKNTREEAVLQRKTAASAPPP 748

  Fly   703 ------SSSSEGDDSSSDEELSASFAEKE--ANQTESTEPAAATLATGLPSMEEIYGCTINPP-S 758
                  ||||| |||.:|.|...|.:::.  ...|::.:.|.||.....| |:|:||.:::.. |
Mouse   749 PSEEAVSSSSE-DDSGTDREDEGSISQRSTPVKMTDTGDSAKATENVVQP-MKEVYGVSLSSSLS 811

  Fly   759 KQSMAVYKKYVQMGKLSSGGARPAQTAVAQRDQEL-AKIMRG-ITLRPLSDYGTDSYLSVRPPVV 821
            ::..::|.::||:|:        :|....:.:|:| ::...| |.|.|:|.:..|:...|:||.|
Mouse   812 EEDHSIYARFVQLGQ--------SQHKQDRGNQQLCSRCSDGVIKLTPISAFSQDNIYEVQPPRV 868

  Fly   822 PRKSLTI----------------------YAEYCRTR 836
            .|||..|                      |.||.|.|
Mouse   869 DRKSTEIFQAHIQASQGIMQPLGKEDTAMYREYIRNR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	312/647 (48%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	173/346 (50%)
Fig4	NP_598760.1	COG5329	14..636	CDD:227637	312/643 (49%)
		Syja_N	93..423	CDD:280532	173/346 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..790		25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837130
Domainoid	1	1.000	314	1.000	Domainoid score	I1297
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6713
Inparanoid	1	1.050	625	1.000	Inparanoid score	I867
Isobase	1	0.950	-	0	Normalized mean entropy	S1362
OMA	1	1.010	-	-		QHG58176
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	1	1.000	-	-		FOG0002534
OrthoInspector	1	1.000	-	-		oto93944
orthoMCL	1	0.900	-	-		OOG6_101803
Panther	1	1.100	-	-	LDO	PTHR45738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R444
SonicParanoid	1	1.000	-	-		X1658
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750