DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and synj1

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	XP_004912203.1	Gene:	synj1 / 100487517	XenbaseID:	XB-GENE-956330	Length:	1548	Species:	Xenopus tropicalis

Alignment Length:	509	Identity:	144/509 - (28%)
Similarity:	223/509 - (43%)	Gaps:	108/509 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KVTSAYGVLGFVRFLEG----YYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV--NEVTSQRPPHP 138
            ||..|||:||.:|...|    |||:|||.   |..:|:     |:|:.:.||  .:..|.|....
Frog    55 KVMDAYGLLGVLRLNLGDSMSYYLVLVTG---CMSVGK-----IQDSEVFRVTSTDFISLRMDPM 111

  Fly   139 HEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKA 203
            .|||...:.:.:: ..:|||::|               ..|..:||..:               |
Frog   112 AEDRMSEVRKVLN-SGSFYFAWS---------------STGVSLDLSLN---------------A 145

  Fly   204 HERVDYAFRSDSRKRFVWNAYLLQPME--GIMLKDWLLEVTHGFVSQSCISIFGRHVNVCLVARR 266
            | |.....|:|:  ||.||..|...::  |:...:|||.:..|.|....|....:....|:::|.
Frog   146 H-RSTQEHRTDN--RFFWNQSLHLHLKHYGVNCDEWLLRLMCGGVEIRTIYAGHQQAKACIISRL 207

  Fly   267 SSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQL 331
            |...|||||..||.|..|..||.|||||::.....:.:|.|:|||||..|.|        |.:|:
Frog   208 SCERAGTRFNVRGTNDYGQAANFVETEQVIYLDDCVSSFIQIRGSIPLFWEQ--------PGLQV 264

  Fly   332 DI--------CDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQF 388
            ..        .:..|.....||..|...||...| :||:..:|   .||::|:..:      |..
Frog   265 GSHRVRMSRGFEANAPAFDRHFLTLKRLYGKQFI-VNLLGSKE---GESMLSRAFQ------NHL 319

  Fly   389 LPPPH--RMKHIHFDMARQSRLSGGNVMEQLAIHA------ESIVQMTGMFFKAAGSEPGLQTGI 445
            ....|  .::.::||..:..|  ||...:   :|:      .:.::..|.||.........|.|.
Frog   320 KASEHSASIQMMNFDYHQMVR--GGKAEK---LHSVLKPKVNTFLEECGFFFLDKNGVHRTQIGT 379

  Fly   446 VRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVT----MLENLYEEHGDTLA 506
            :|:||:||||||||.|..:|...|..|||.||..:..:|      ||    :..:::..:||:::
Frog   380 IRSNCLDCLDRTNSVQAFLGLEMLLKQLEVLGLAEKPQL------VTRFQEVFRSMWSTNGDSIS 438

  Fly   507 LQYGGS-QLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFL 559
            ..|.|: .|..:.|        |.:..|..::::|...|.|.|..||.:|::.|
Frog   439 KIYAGTGALEGKAK--------GGKLKDGARSVTRTIQNNFFDGSKQEAIDVLL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	144/509 (28%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	94/339 (28%)
synj1	XP_004912203.1	COG5329	9..484	CDD:227637	143/507 (28%)
		EEP	537..872	CDD:382041
		RRM_SF	871..987	CDD:388407
		PHA03247	<1061..1264	CDD:223021
		PHA03378	<1072..1483	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920