DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and fig4

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	XP_031757753.1	Gene:	fig4 / 100379892	XenbaseID:	XB-GENE-6047255	Length:	907	Species:	Xenopus tropicalis

Alignment Length:	940	Identity:	377/940 - (40%)
Similarity:	533/940 - (56%)	Gaps:	155/940 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PLISSIQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASL- 75
            |:||.|||::|||||||.:|||||:.|||:|:|.|||.....|.|.::.:.:...|:|..:..|
Frog     6 PIISGIQKLILYETRARYFLVGSNHAETRYRVLKIDRTEPKDLVIIDDKHVYTQQEVRELLGRLD 70

  Fly    76 ------------SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV- 127
                        ||..:..||:|::|||:||||||::|:|||:..|.||.|.:|.|:||.|:.:
Frog    71 LGNRTKMGQKGSSGLSRAVSAFGIVGFVQFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIP 135

  Fly   128 NEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYN-------------ESAPRYVG 179
            |:  |.|..||.|.||.|:|||:||.|||||||||||:.:||||             |:||....
Frog   136 ND--SVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTILRMPAEMLKSETAPHTRQ 198

  Fly   180 AKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPMEGIMLKDWLLEVTHG 244
            ...|:..||.|.  |...|.|        :...|:...::|||..|||.:..::.:||||.:.||
Frog   199 EGFDIFEDEELS--NQGGSGV--------FGICSEPYMKYVWNGELLQNVRDVVHRDWLLYIIHG 253

  Fly   245 FVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFT--- 306
            |..||.:.|:||.|.|.|:||||||||||||||||||.:|||||||||||||.|.. :.:||
Frog   254 FCGQSKLLIYGRPVYVTLMARRSSRFAGTRFLKRGANCEGDVANEVETEQIVHDAS-VMSFTAGS 317

  Fly   307 -----QMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRE 366
                 |:|||:|.:||||||.|:|||.|.||..||:|...::||:::|..:|:|:|:|||||:||
Frog   318 YSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAYAAAIHFDKMLQRFGSPIIILNLVKERE 382

  Fly   367 RRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMTGMF 431
            :||||.|:|:||..::.||||||||.|.:.:|.:|||:.::....||:::|.:.|||:|:.||.|
Frog   383 KRKHERILSEELVAAVTYLNQFLPPEHWIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFF 447

  Fly   432 FK--------------------AAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERL 476
            ..                    ..|....||||::||||||||||||:|||.:|||||.:||..|
Frog   448 VNRPDPYCSVLRPDEKWNELGGVVGQSGRLQTGVLRTNCVDCLDRTNTAQFMVGKCALAYQLYSL 512

  Fly   477 GFVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRY 541
            |.:....|:||:|.|.:.|.|||:|||||:|||||||||||:|||||.|||.....|:|||||||
Frog   513 GLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRY 577

  Fly   542 YSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHNAFVPRAD--SKAITDWVRHKVR 604
            |||.|||.::|.:||||||:::|:..|  |.:|||.||:.:|:......|  .::.|.|...||.
Frog   578 YSNAFSDADRQDAINLFLGVFRPAEGK--PHLWELPTDFYLHHKNTMGLDHAKRSYTFWWTPKVL 640

  Fly   605 ACLPYSCAD---SNKLVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEISQLALRYMP-T 665
            ..||....:   |..|.|...:..:...:..:.|:.:.:.::.::|.:.....::..|..:|| :
Frog   641 ENLPLPLDEVHSSENLKKMTIKKCNRSNDETNIYNEFFRPYELSNFDDTFCLAMTNSARDFMPKS 705

  Fly   666 FRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNS---------------------SSSSEGD 709
            ...:.|||     |.||    |..||:|.:|:.::..                     ||||| |
Frog   706 VAIDPSPF-----TVRK----PDETGKSVSGNKSNKEETVLQRKTAASAPPPHGEEAVSSSSE-D 760

  Fly   710 DSSSDEELSASFAEKEAN-QTESTEPAAATLATGLPSMEEIYGCTINP-PSKQSMAVYKKYVQMG 772
            ||.:|:|...|.:::... :...|.....|....:.|.::.||..::. ||:..:.:|.::|.:|
Frog   761 DSGTDKEDEGSVSQRSTPVKNSDTGDNTKTSENYMQSTKDSYGINLSDVPSENDLQIYTRFVHLG 825

  Fly   773 KLSSGGARPAQTAVAQRDQELAKIMRGITLRP---------LSDYGTDSYLSVRPPVVPRKSLTI 828
                         :.|:.|:  |....|:.:|         :|.:..|:...|:||.|.|||:.|
Frog   826 -------------ICQQKQD--KRTLHISSKPFESFAKLSCISSFSHDNIYEVQPPKVDRKSVEI 875

  Fly   829 ----------------------YAEYCRTR 836
                                  |.||.|.|
Frog   876 FTAHIQAGHGIMQPLGKEDMLMYREYIRNR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	307/636 (48%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	173/343 (50%)
fig4	XP_031757753.1	COG5329	13..656	CDD:227637	313/657 (48%)
fig4	XP_031757753.1	Syja_N	92..423	CDD:396798	173/343 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1252
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6713
Inparanoid	1	1.050	609	1.000	Inparanoid score	I914
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219218at33208
OrthoFinder	1	1.000	-	-		FOG0002534
OrthoInspector	1	1.000	-	-		oto104169
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1658
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060