DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIG4 and fig4a

DIOPT Version :9

Sequence 1:	NP_608841.1	Gene:	FIG4 / 33658	FlyBaseID:	FBgn0031611	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	XP_021324399.1	Gene:	fig4a / 100334605	ZFINID:	ZDB-GENE-130213-1	Length:	901	Species:	Danio rerio

Alignment Length:	937	Identity:	382/937 - (40%)
Similarity:	535/937 - (57%)	Gaps:	139/937 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LISSIQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASL-- 75
            :|..:||:||||||||.:||||||.:|:.|:|.|||.....|.|.::.:.::..|:|..:..|
Zfish     7 VIRGVQKLVLYETRARYFLVGSNNAQTKHRVLKIDRTEPRDLVIIDDKHVYSQQEVRELLGRLDL 71

  Fly    76 -----------SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV-N 128
                       ||..:..||||::||||||||||::|:|||:..|.||.|.:|.|:||.|:.: |
Zfish    72 GNRTKMGQKGSSGLSRAVSAYGIVGFVRFLEGYYIVLITKRRKMADIGGHSIYKIEDTNMIYIPN 136

  Fly   129 EVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYN-----------ESAPRYVGAK- 181
            :  |.|..||.|.||.|:|||:||.||||||||||::.:||||           ||.....|.:
Zfish   137 D--SVRVTHPDEARYVRIFQNVDLSSNFYFSYSYDVSHSLQYNLTLLQSWSVCVESESGAAGRQD 199

  Fly   182 -VDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPMEGIMLKDWLLEVTHGF 245
             .|:..:|.||             .:|.:....:...::|||..||:.::.|:..||||.:.|||
Zfish   200 TFDIFEEEGLP-------------TQVVHGLSHEPYSKYVWNLRLLEKVKEIVHPDWLLYIIHGF 251

  Fly   246 VSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQ-------RIC 303
            ..||.:.|:||.|.|.|:||||||||||||||||||.:||||||||||||:.|..       ...
Zfish   252 CGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQIIHDASVMSLSAGSFS 316

  Fly   304 AFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERR 368
            :..|:|||:|.|||||||.|:|||.|:||..||:|...:|||::::..:|:|:|:||||||||:|
Zfish   317 SCVQVRGSVPLHWSQDISTMMPKPPIRLDQADPFAHVAALHFDQMMQRFGSPIIILNLVKKREKR 381

  Fly   369 KHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMTGMF-- 431
            |||.|:|:||..:|..|||||||.|.:::|.:||||.::....||:::|::.|||:|:.||.|
Zfish   382 KHEKILSEELYRAITNLNQFLPPEHNIEYIAWDMARYTKSKLCNVLDRLSMIAESVVKRTGFFVN 446

  Fly   432 ---FKAAGSEPG---------------LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGF 478
               |......|.               ||||::||||||||||||:|||.:|||||.:||..||.
Zfish   447 RPDFYCHSLRPDERWGDLGGTVTPNGRLQTGVLRTNCVDCLDRTNTAQFMVGKCALAYQLYALGM 511

  Fly   479 VKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYS 543
            :...||:||:|||.:.|.|||:|||||:|||||||||||:|||||.|||.....|:|||||||||
Zfish   512 IDKPKLQFDTDCVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYS 576

  Fly   544 NTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMH--NAFVPRADSKAITDWVRHKVRAC 606
            |.|||.::|.:|||||.:::||.||  |.:|||.||:.:|  |.........:.|.|....|...
Zfish   577 NAFSDADRQDAINLFLQVFQPSETK--PHLWELPTDFYLHHSNTMTLPHHRHSYTHWWTGGVLTY 639

  Fly   607 LPY-----SCADSNK--LVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEISQLALRYMP 664
            ||.     .|.::.|  .||.:.|..    |..|.|:.:.:.::.|.|.:..:..::..|..:||
Zfish   640 LPLPFDEAQCEENMKKVSVKRVNRYE----ESTDIYTEFFKPYELTAFDDTFSISMTNSARDFMP 700

  Fly   665 -TFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNS---------------------SSSSE 707
             |...:.|||     |.||    |..:.:|..||.:|..                     |||||
Zfish   701 KTVGLDPSPF-----TVRK----PDESAKSVLGSKSSKEEAVLQRKTAASAPPPPTEEQISSSSE 756

  Fly   708 GDDSSSDEELSASFAEKEA----NQTESTEPAAATLATGLPSMEEIYGCTI--NPPSKQSMAVYK 766
             |||..|.|..||.:::..    .:|...:|..   ...||:..|.||..:  :||. :.:.:|.
Zfish   757 -DDSEDDREDDASASQRSTPIRLTETSHEDPGP---QQRLPAARETYGLNLLASPPD-EDILIYH 816

  Fly   767 KYVQMGKLSSGGARPAQTAVAQRDQELAKIMRGITLRPLSDYGTDSYLSVRPPVVPRKSLTIYAE 831
            ::..:|:         .....:|..::.|....|:|.|:|.:.:||...|..|.|..:|..::..
Zfish   817 RFAHLGQ---------NQHKVERHDDMKKSDAVISLAPVSVFASDSIYEVCAPEVDVQSRNLFET 872

  Fly   832 YCRTRSTFNAVPKLEEFDVLY--QYVQ 856
            :.:|...:  |..|.:.|||.  :|::
Zfish   873 HVQTARGW--VRTLGQEDVLMYREYIR 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_608841.1	COG5329	19..599	CDD:227637	309/635 (49%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:280532	171/342 (50%)
fig4a	XP_021324399.1	Syja_N	92..420	CDD:308153	171/342 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580692
Domainoid	1	1.000	233	1.000	Domainoid score	I2344
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6713
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219218at33208
OrthoFinder	1	1.000	-	-		FOG0002534
OrthoInspector	1	1.000	-	-		oto40638
orthoMCL	1	0.900	-	-		OOG6_101803
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1658
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.750