DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF845

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	337	Identity:	111/337 - (32%)
Similarity:	162/337 - (48%)	Gaps:	39/337 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RRTRVSIAEMIAQCTGFEVKRGDLF---SEMICPQCYEDVKSAYGIRQTCEESHQFYCRVRDEGI 84
            |..|:...|...||.    :.|..|   |.:|..|....:...|    .|.:.||.:..
Human   540 RHCRLHTGEKPYQCN----ECGKAFRGQSALIYHQAIHGIGKLY----KCNDCHQVFSN------ 590

  Fly    85 EDALCALLEEEDWEISEDEDA----------RIDSASAADDDGKSDSKKVAFECRECHKKYQRKG 139
                 |......|.|..:|.:          |..|..|.  ..::.|.:..::|.||.:.:..|.
Human   591 -----ATTIANHWRIHNEERSYKCNRCGKFFRHRSYLAV--HWRTHSGEKPYKCEECDEAFSFKS 648

  Fly   140 TFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTH 204
            ...||.|.|...:.:.|..|.:.|..:..|..|.:.|...|||:|:.|.|||.:.|.|..|:..|
Human   649 NLQRHRRIHTGEKPYRCNECGKTFSRKSYLTCHRRLHTGEKPYKCNECGKTFGRNSALIIHKAIH 713

  Fly   205 TGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCS 269
            |||:|:||::|.|.|.:.|.|..|:|.|..|:|:||.:|.|.|:||..|:.|.|.||||:|:||.
Human   714 TGEKPYKCNECGKAFSQKSSLTCHLRLHTGEKPYKCEECDKVFSRKSSLEKHRRIHTGEKPYKCK 778

  Fly   270 HCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQR 334
            .|.|||....||.||:|:|..::|::|:.|.|.||.:|.|..||.:|:.|:.:||..|...::..
Human   779 VCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFRHNSALVIHKAIHSGEKPYKCNECGKTFRHN 843

  Fly   335 KTLARHILEIHK 346
            ..     |||||
Human   844 SA-----LEIHK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	14/57 (25%)
		C2H2 Zn finger	128..148	CDD:275368	7/19 (37%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		COG5048	<180..341	CDD:227381	70/160 (44%)
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	197..219	CDD:290200	11/21 (52%)
		C2H2 Zn finger	212..232	CDD:275368	8/19 (42%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	9/19 (47%)
		zf-H2C2_2	252..276	CDD:290200	13/23 (57%)
		C2H2 Zn finger	268..288	CDD:275368	10/19 (53%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..341	CDD:275368	2/16 (13%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	7/27 (26%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	369..394	CDD:290200
		COG5048	381..813	CDD:227381	95/293 (32%)
		C2H2 Zn finger	385..405	CDD:275368
		zf-H2C2_2	397..422	CDD:290200
		C2H2 Zn finger	413..433	CDD:275368
		C2H2 Zn finger	441..461	CDD:275368
		zf-H2C2_2	453..478	CDD:290200
		C2H2 Zn finger	469..489	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:290200
		C2H2 Zn finger	525..545	CDD:275368	2/4 (50%)
		zf-H2C2_2	537..560	CDD:290200	6/23 (26%)
		C2H2 Zn finger	553..573	CDD:275368	6/23 (26%)
		C2H2 Zn finger	581..601	CDD:275368	5/30 (17%)
		C2H2 Zn finger	609..629	CDD:275368	3/21 (14%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		zf-H2C2_2	649..674	CDD:290200	7/24 (29%)
		C2H2 Zn finger	665..685	CDD:275368	5/19 (26%)
		C2H2 Zn finger	693..713	CDD:275368	8/19 (42%)
		C2H2 Zn finger	721..741	CDD:275368	8/19 (42%)
		C2H2 Zn finger	749..769	CDD:275368	9/19 (47%)
		zf-H2C2_2	761..786	CDD:290200	14/24 (58%)
		C2H2 Zn finger	777..797	CDD:275368	10/19 (53%)
		C2H2 Zn finger	805..825	CDD:275368	9/19 (47%)
		C2H2 Zn finger	833..853	CDD:275368	7/23 (30%)
		zf-H2C2_2	845..870	CDD:290200	5/11 (45%)
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910