DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF835

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001005850.2	Gene:	ZNF835 / 90485	HGNCID:	34332	Length:	537	Species:	Homo sapiens

Alignment Length:	306	Identity:	104/306 - (33%)
Similarity:	146/306 - (47%)	Gaps:	43/306 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RQTCEESHQFYCRVRDEGIEDALCALLEEEDWEISEDEDARI---------DSASAADDD----- 116
            :::|.|.....|:....|            |.....||.:||         ..||..||.
Human    31 QESCPEPEAVACKGDPAG------------DSMQERDEFSRIPRTISSPAATQASVPDDSSSRRC 83

  Fly   117 ---GKS------DSK--------KVAFECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFR 164
               |:|      ||:        |..::|.:|.|.:.....|:.|.|.|...:.|.||.|.:.|.
Human    84 SAPGESPKERHPDSRQRERGGGPKKPWKCGDCGKAFSYCSAFILHQRIHTGEKPFACPECGKAFS 148

  Fly   165 LRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHI 229
            ..|.|..|.:||...|||.|..|.|.|:|.|.|.||.||||||:|.:|:.|.|.|.:.:.|.:|.
Human   149 QSVHLTLHQRTHTGEKPYACHECGKAFSQGSYLASHWRTHTGEKPHRCADCGKAFTRVTHLTQHR 213

  Fly   230 RTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPF 294
            |.|..|||:.|::|.|.|..:..|..|.|.||||:|::||.|.|||.....|.:|.|:|..::|:
Human   214 RVHTGERPYACAQCAKAFRNRSSLIEHQRIHTGEKPYECSACAKAFRFSSALIRHQRIHTEEKPY 278

  Fly   295 RCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARH 340
            ||..|.|.|...:.|.:|:.||..|:.:.|..|.:.:.|..:||.|
Human   279 RCGQCAKAFAQIAHLTQHRRVHTGEKPYTCQDCGALFSQSASLAEH 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	2/11 (18%)
		C2H2 Zn finger	128..148	CDD:275368	6/19 (32%)
		C2H2 Zn finger	156..176	CDD:275368	7/19 (37%)
		COG5048	<180..341	CDD:227381	69/161 (43%)
		C2H2 Zn finger	184..204	CDD:275368	10/19 (53%)
		zf-H2C2_2	197..219	CDD:290200	13/21 (62%)
		C2H2 Zn finger	212..232	CDD:275368	7/19 (37%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		zf-H2C2_2	252..276	CDD:290200	13/23 (57%)
		C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		C2H2 Zn finger	324..341	CDD:275368	6/17 (35%)
ZNF835	NP_001005850.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..109		18/89 (20%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		zf-H2C2_2	128..149	CDD:290200	8/20 (40%)
		COG5048	136..487	CDD:227381	79/189 (42%)
		C2H2 Zn finger	140..160	CDD:275368	7/19 (37%)
		zf-H2C2_2	152..177	CDD:290200	11/24 (46%)
		C2H2 Zn finger	168..188	CDD:275368	10/19 (53%)
		Ribosomal_L34e	178..>243	CDD:294621	28/64 (44%)
		C2H2 Zn finger	196..216	CDD:275368	7/19 (37%)
		C2H2 Zn finger	224..244	CDD:275368	7/19 (37%)
		zf-H2C2_2	236..259	CDD:290200	12/22 (55%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		zf-H2C2_2	264..289	CDD:290200	10/24 (42%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		zf-H2C2_2	292..317	CDD:290200	7/24 (29%)
		C2H2 Zn finger	308..328	CDD:275368	6/17 (35%)
		zf-H2C2_2	320..345	CDD:290200	3/5 (60%)
		C2H2 Zn finger	336..356	CDD:275368
		zf-H2C2_2	348..373	CDD:290200
		C2H2 Zn finger	364..384	CDD:275368
		zf-H2C2_2	376..401	CDD:290200
		C2H2 Zn finger	392..412	CDD:275368
		zf-H2C2_2	404..429	CDD:290200
		C2H2 Zn finger	420..440	CDD:275368
		zf-H2C2_2	432..457	CDD:290200
		C2H2 Zn finger	448..468	CDD:275368
		zf-C2H2	474..496	CDD:278523
		C2H2 Zn finger	476..496	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910