DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG15436 and ZNF426

DIOPT Version :9

Sequence 1:NP_608840.1 Gene:CG15436 / 33657 FlyBaseID:FBgn0031610 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_077011.1 Gene:ZNF426 / 79088 HGNCID:20725 Length:554 Species:Homo sapiens


Alignment Length:248 Identity:87/248 - (35%)
Similarity:124/248 - (50%) Gaps:29/248 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 FECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKT 190
            :||:||.|.:....:|..|.|||...:.:.|..|.:.|.....|..|:::|:..|||||..|.|:
Human   308 YECKECGKAFNYSNSFQIHGRTHTGEKPYVCKECGKAFTQYSGLSMHVRSHSGDKPYECKECGKS 372

  Fly   191 FAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSD----------------------------LRR 227
            |...|.|..|.||||||:||.|.:|.|.|..||:                            |..
Human   373 FLTSSRLIQHIRTHTGEKPFVCVECGKAFAVSSNLSGHLRTHTEEKACECKICGKVFGYPSCLNN 437

  Fly   228 HIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDR 292
            |:|||.:::|:.|.:|.|.|....||..|.|.||||:|::|..|.|||:.....:.|.|.|..::
Human   438 HMRTHSAQKPYTCKECGKAFNYSTHLKIHMRIHTGEKPYECKQCGKAFSHSSSFQIHERTHTGEK 502

  Fly   293 PFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARHILEIH 345
            |:.|..|.|.|..||:.:.|:..|..|:.:||..|...|...::|.|| .:||
Human   503 PYECKECGKAFTCSSSFRIHEKTHTEEKPYKCQQCGKAYSHPRSLRRH-EQIH 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15436NP_608840.1 zf-AD 4..78 CDD:285071
C2H2 Zn finger 128..148 CDD:275368 7/19 (37%)
C2H2 Zn finger 156..176 CDD:275368 5/19 (26%)
COG5048 <180..341 CDD:227381 68/188 (36%)
C2H2 Zn finger 184..204 CDD:275368 8/19 (42%)
zf-H2C2_2 197..219 CDD:290200 13/21 (62%)
C2H2 Zn finger 212..232 CDD:275368 9/47 (19%)
zf-H2C2_2 224..249 CDD:290200 10/52 (19%)
C2H2 Zn finger 240..260 CDD:275368 8/19 (42%)
zf-H2C2_2 252..276 CDD:290200 13/23 (57%)
C2H2 Zn finger 268..288 CDD:275368 7/19 (37%)
C2H2 Zn finger 296..316 CDD:275368 7/19 (37%)
C2H2 Zn finger 324..341 CDD:275368 5/16 (31%)
ZNF426NP_077011.1 KRAB 42..98 CDD:214630
C2H2 Zn finger 148..168 CDD:275368
C2H2 Zn finger 176..214 CDD:275368
zf-C2H2 224..246 CDD:306579
C2H2 Zn finger 226..246 CDD:275368
C2H2 Zn finger 282..302 CDD:275368
zf-H2C2_2 294..319 CDD:316026 5/10 (50%)
C2H2 Zn finger 310..330 CDD:275368 7/19 (37%)
COG5048 <334..486 CDD:227381 54/151 (36%)
C2H2 Zn finger 338..358 CDD:275368 5/19 (26%)
C2H2 Zn finger 366..386 CDD:275368 8/19 (42%)
C2H2 Zn finger 394..414 CDD:275368 6/19 (32%)
C2H2 Zn finger 422..442 CDD:275368 3/19 (16%)
C2H2 Zn finger 450..470 CDD:275368 8/19 (42%)
C2H2 Zn finger 478..498 CDD:275368 7/19 (37%)
zf-H2C2_2 490..515 CDD:316026 8/24 (33%)
C2H2 Zn finger 506..526 CDD:275368 7/19 (37%)
C2H2 Zn finger 534..554 CDD:275368 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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