Protein Alignment Paris and ZNF16

DIOPT Version :10

• Sequence 1: NP_608840.1
• Gene: Paris / 33657
• FlyBaseID: FBgn0031610
• Length: 346
• Species: Drosophila melanogaster
• Sequence 2: NP_008889.2
• Gene: ZNF16 / 7564
• HGNCID: 12947
• Length: 682
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 116/396 - (29%)
• Similarity: 183/396 - (46%)
• Gaps: 70/396 - (17%)

  Fly     3 EICRVCMDISGKLVNIFDARR-----------------RTRVSIAEMIAQCTGFEVKRGDLFSEM 50
            |:..:|.|:|.:...:.:.||                 ..|..:.|....|.||:.:.....:.|
Human   105 ELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDSRFSLSPNLM 169

  Fly    51 IC--------PQCYE----------DVKSAYGIRQT-----CEESHQFYCRVRDEGIEDALCALL 92
            .|        |..|:          |:....|:...     |.|     |....:|..|    |:
Human   170 ACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNE-----CGKTFQGNPD----LI 225

  Fly    93 EEEDWEISEDEDARIDSASAADDDGKSDSK-------------KVAFECRECHKKYQRKGTFLRH 144
            :.:.....|       ::...||.||:.|:             :.|::|.||.|.::....|.||
Human   226 QRQIVHTGE-------ASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRH 283

  Fly   145 MRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERP 209
            ...|...:.:.|..|.:.|....:||.|.|:|.:.|||||:.|.|.|.:.|.|..|:|.|:||:|
Human   284 QSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKP 348

  Fly   210 FKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKA 274
            :.||:|.|.|.:||:|.:|.|||..|:||:|.:|.|.|::..||..|.|.||||:|::|:.|.|.
Human   349 YVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKP 413

  Fly   275 FAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLAR 339
            |:...:|.:|.|:|..::|::||.|.|.|..||:|.:|:.:|..|:...|..|...:.....|.:
Human   414 FSRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRK 478

  Fly   340 HILEIH 345
            |.: ||
Human   479 HQI-IH 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Paris	NP_608840.1	zf-AD	4..78	CDD:462262	18/113 (16%)
		C2H2 Zn finger	128..148	CDD:275368	7/19 (37%)
		C2H2 Zn finger	156..176	CDD:275368	7/19 (37%)
		COG5048	<180..341	CDD:227381	67/160 (42%)
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		C2H2 Zn finger	212..232	CDD:275368	10/19 (53%)
		C2H2 Zn finger	240..260	CDD:275368	8/19 (42%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..341	CDD:275368	3/16 (19%)
ZNF16	NP_008889.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210		17/104 (16%)
		COG5048	<160..369	CDD:227381	60/224 (27%)
		C2H2 Zn finger	187..203	CDD:275368	2/15 (13%)
		C2H2 Zn finger	211..231	CDD:275368	6/28 (21%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		Required for nuclear localization	268..393		51/124 (41%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		COG5048	303..675	CDD:227381	75/182 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		Required for nuclear localization	341..373		17/31 (55%)
		C2H2 Zn finger	351..371	CDD:275368	10/19 (53%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
		C2H2 Zn finger	435..455	CDD:275368	9/19 (47%)
		C2H2 Zn finger	463..483	CDD:275368	4/20 (20%)
		Required for nuclear localization	473..503		4/12 (33%)
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368