DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF287

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001333096.1	Gene:	ZNF287 / 57336	HGNCID:	13502	Length:	761	Species:	Homo sapiens

Alignment Length:	371	Identity:	112/371 - (30%)
Similarity:	176/371 - (47%)	Gaps:	64/371 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AEICRVCMDISG---------KLVNIFD----ARRRTRVSIAEMIAQCTGFEVKRGDLFSEMICP 53
            |:.|....|:|.         ||.:.:|    ..||.:....::.....||.:|  .:.|:...|
Human   244 AQACTPVEDMSKLTKEETHTIKLEDSYDYDDRLERRGKGGFWKIHTDERGFSLK--SVLSQEYDP 306

  Fly    54 QCYEDVKSAYGIRQTCEESH-----QFYCRVRDEGIEDALCALLEEEDWEISEDEDARIDSASAA 113
            .  |:..|.|.|.:...|.|     ||                            |.::|:.::.
Human   307 T--EECLSKYDIYRNNFEKHSNLIVQF----------------------------DTQLDNKTSV 341

  Fly   114 DDDGKSDSKKVA--------------FECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFR 164
            .::|::....|:              ::|..|.||:::..:.|:|..||...:|:.|..|.:.||
Human   342 YNEGRATFNHVSYGIVHRKILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFR 406

  Fly   165 LRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHI 229
            ...:|.||.:.|...|||||..|.|.|:|::.|..|:|.||||:|:||..|.|.|.:.:.|..|.
Human   407 HISSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQ 471

  Fly   230 RTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPF 294
            |||..|:|:||.:|.|||:....|.||.|.||||:|:.|:.|.|.|:...||.||.::|...:|:
Human   472 RTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPY 536

  Fly   295 RCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARH 340
            :|:.|.|.|..|:.|..|:.:|:.|:.:||..|...:....||.:|
Human   537 KCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQH 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	21/91 (23%)
		C2H2 Zn finger	128..148	CDD:275368	6/19 (32%)
		C2H2 Zn finger	156..176	CDD:275368	7/19 (37%)
		COG5048	<180..341	CDD:227381	69/161 (43%)
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	197..219	CDD:290200	12/21 (57%)
		C2H2 Zn finger	212..232	CDD:275368	7/19 (37%)
		zf-H2C2_2	224..249	CDD:290200	13/24 (54%)
		C2H2 Zn finger	240..260	CDD:275368	9/19 (47%)
		zf-H2C2_2	252..276	CDD:290200	12/23 (52%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..341	CDD:275368	5/17 (29%)
ZNF287	NP_001333096.1	SCAN	46..144	CDD:413396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..154
		KRAB	170..227	CDD:214630
		SFP1	<364..419	CDD:227516	16/54 (30%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		COG5048	422..755	CDD:227381	69/161 (43%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		C2H2 Zn finger	482..502	CDD:275368	9/19 (47%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		C2H2 Zn finger	566..586	CDD:275368	5/17 (29%)
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
		C2H2 Zn finger	650..670	CDD:275368
		C2H2 Zn finger	678..698	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	734..754	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910