DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF470

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001001668.3	Gene:	ZNF470 / 388566	HGNCID:	22220	Length:	717	Species:	Homo sapiens

Alignment Length:	392	Identity:	110/392 - (28%)
Similarity:	183/392 - (46%)	Gaps:	66/392 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CRVCMDISGKLVNIFDARRRTRVSIAEMIAQCTGFEVKRGDLFSEMI----------------CP 53
            |..|..|..|:..:   ....|:...|...:|    ::.|..||:..                |.
Human   230 CNDCEKIFSKISTL---TLHQRIHTGEKPYEC----IECGKAFSQSAHLAQHQRIHTGEKPFECT 287

  Fly    54 QCYEDV-KSAYGIR----QTCEESHQFYCRVRDEGIEDALCALLE-------EEDWEISEDEDAR 106
            :|.:.. ::|:.::    .|.|:.:|  |:..::.... |..|.:       |:.:|..|...|.
Human   288 ECGKAFSQNAHLVQHQRVHTGEKPYQ--CKQCNKAFSQ-LAHLAQHQRVHTGEKPYECIECGKAF 349

  Fly   107 IDSASAAD--------------DDGKSDSKKVA--------------FECRECHKKYQRKGTFLR 143
            .|.:|.|.              |.||:..:..:              |:|.:|.|.:......::
Human   350 SDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPFDCIDCGKAFTDHIGLIQ 414

  Fly   144 HMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGER 208
            |.|||...:.:.|..|.:.|....:|..|.:.|...|||||:.|.|.|:.:.:|..|:|.||||:
Human   415 HKRTHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICEKAFSHRGSLTLHQRVHTGEK 479

  Fly   209 PFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPK 273
            |::|.:|.|.|.:|:.|..|.|.|..|:|::|.:|:|||::..||..|.:.||||:|::|..|.|
Human   480 PYECKECGKAFRQSTHLAHHQRIHTGEKPYECKECSKTFSQNAHLAQHQKIHTGEKPYECKECGK 544

  Fly   274 AFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLA 338
            ||:...||.||.|:|..::|:.|..|.|.|...|.|.:|:.:|:.:|.::|..|...::||.:|.
Human   545 AFSQIAHLVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRLHSGKRPYECLECGKAFRQRASLI 609

  Fly   339 RH 340
            .|
Human   610 CH 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	16/93 (17%)
		C2H2 Zn finger	128..148	CDD:275368	5/19 (26%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		COG5048	<180..341	CDD:227381	67/161 (42%)
		C2H2 Zn finger	184..204	CDD:275368	7/19 (37%)
		zf-H2C2_2	197..219	CDD:290200	11/21 (52%)
		C2H2 Zn finger	212..232	CDD:275368	8/19 (42%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	8/19 (42%)
		zf-H2C2_2	252..276	CDD:290200	12/23 (52%)
		C2H2 Zn finger	268..288	CDD:275368	10/19 (53%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..341	CDD:275368	6/17 (35%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630
		KRAB	23..62	CDD:279668
		Nuclear localization signal. /evidence=ECO:0000255	216..219
		C2H2 Zn finger	230..250	CDD:275368	5/22 (23%)
		zf-H2C2_2	243..267	CDD:290200	5/30 (17%)
		COG5048	254..669	CDD:227381	104/365 (28%)
		C2H2 Zn finger	258..278	CDD:275368	4/23 (17%)
		zf-H2C2_2	270..295	CDD:290200	2/24 (8%)
		C2H2 Zn finger	286..306	CDD:275368	3/19 (16%)
		zf-H2C2_2	298..323	CDD:290200	4/26 (15%)
		C2H2 Zn finger	314..334	CDD:275368	3/20 (15%)
		zf-H2C2_2	326..350	CDD:290200	5/23 (22%)
		C2H2 Zn finger	342..362	CDD:275368	5/19 (26%)
		zf-H2C2_2	354..379	CDD:290200	5/24 (21%)
		C2H2 Zn finger	370..388	CDD:275368	3/17 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		0/2 (0%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		zf-H2C2_2	412..436	CDD:290200	7/23 (30%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	467..492	CDD:290200	12/24 (50%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		zf-H2C2_2	495..520	CDD:290200	11/24 (46%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		zf-H2C2_2	523..548	CDD:290200	13/24 (54%)
		C2H2 Zn finger	539..559	CDD:275368	10/19 (53%)
		zf-H2C2_2	551..575	CDD:290200	10/23 (43%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	6/17 (35%)
		zf-H2C2_2	607..632	CDD:290200	2/5 (40%)
		C2H2 Zn finger	623..643	CDD:275368
		zf-H2C2_2	635..660	CDD:290200
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910