DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF808

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001034975.2	Gene:	ZNF808 / 388558	HGNCID:	33230	Length:	903	Species:	Homo sapiens

Alignment Length:	390	Identity:	110/390 - (28%)
Similarity:	172/390 - (44%)	Gaps:	91/390 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CRVCMDI--SGKLVNIFDARRRTRVSIAEMIAQCTGFEVKRGDLFSEMI---------------- 51
            |.||..:  ...::.:     .||:..|:...:|.    :.|..|::..
Human   541 CTVCNKVFMRNSVLAV-----HTRIHTAKKPYKCN----ECGKAFNQQSHLSRHRRLHTGEKPYK 596

  Fly    52 CPQCYEDVKSAYGIRQTCEESHQ--------FYCRVRDEGIEDALCALLEEEDWEISEDEDARID 108
            |..|    ...:| :::..|||:        :.|:|.|...           .|........||.
Human   597 CEAC----DKVFG-QKSALESHKRIHTGEKPYRCQVCDTAF-----------TWNSQLARHTRIH 645

  Fly   109 SASAADDDGKSDSKKVAFECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHM 173
            :.            :..::|.||.|.:..|.:.:.|.|.|...:|:.|..|.:.|..|..:..|.
Human   646 TG------------EKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHT 698

  Fly   174 KTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPF 238
            :.|:..|||:|:.|:|||:.:|:|..|.|.|:||:|:|||:|||||.:.:.|..|.|.|..|:|:
Human   699 RIHSGMKPYKCNECSKTFSNRSSLVCHRRIHSGEKPYKCSECSKTFSQKATLLCHRRLHSGEKPY 763

  Fly   239 KCS-------------------------KCT---KTFTRKFHLDNHFRSHTGERPFKCSHCPKAF 275
            ||:                         |||   |.|.|..:|..|.|.||.|:|:||:.|.|||
Human   764 KCNDCGNTFRHWSSLVYHRRLHTGEKSYKCTVCDKAFVRNSYLARHIRIHTAEKPYKCNECGKAF 828

  Fly   276 AMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARH 340
            ..:.||.:|.|:|..::|::|..|.|.|...|.||.|:::|..|:.:||..|...:..|.||..|
Human   829 NEQSHLSRHHRIHTGEKPYKCEACDKVFSRKSHLKRHRIIHTGEKPYKCNECGKAFSDRSTLIHH 893

Fly 341 340
Human 894 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	15/98 (15%)
		C2H2 Zn finger	128..148	CDD:275368	7/19 (37%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		COG5048	<180..341	CDD:227381	74/189 (39%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..219	CDD:290200	13/21 (62%)
		C2H2 Zn finger	212..232	CDD:275368	10/19 (53%)
		zf-H2C2_2	224..249	CDD:290200	13/52 (25%)
		C2H2 Zn finger	240..260	CDD:275368	10/47 (21%)
		zf-H2C2_2	252..276	CDD:290200	12/23 (52%)
		C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..341	CDD:275368	6/17 (35%)
ZNF808	NP_001034975.2	KRAB	24..64	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154
		COG5048	206..585	CDD:227381	9/52 (17%)
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	261..281	CDD:275368
		C2H2 Zn finger	289..309	CDD:275368
		C2H2 Zn finger	317..337	CDD:275368
		C2H2 Zn finger	345..365	CDD:275368
		C2H2 Zn finger	373..393	CDD:275368
		COG5048	397..839	CDD:227381	90/334 (27%)
		C2H2 Zn finger	401..421	CDD:275368
		C2H2 Zn finger	429..449	CDD:275368
		C2H2 Zn finger	457..477	CDD:275368
		C2H2 Zn finger	485..505	CDD:275368
		C2H2 Zn finger	513..533	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368	5/24 (21%)
		C2H2 Zn finger	569..589	CDD:275368	3/23 (13%)
		C2H2 Zn finger	597..617	CDD:275368	6/24 (25%)
		C2H2 Zn finger	625..645	CDD:275368	5/30 (17%)
		C2H2 Zn finger	653..673	CDD:275368	7/19 (37%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..729	CDD:275368	9/19 (47%)
		C2H2 Zn finger	737..757	CDD:275368	10/19 (53%)
		C2H2 Zn finger	765..785	CDD:275368	1/19 (5%)
		C2H2 Zn finger	793..813	CDD:275368	8/19 (42%)
		SFP1	<816..893	CDD:227516	30/76 (39%)
		C2H2 Zn finger	821..841	CDD:275368	9/19 (47%)
		C2H2 Zn finger	849..869	CDD:275368	8/19 (42%)
		C2H2 Zn finger	877..897	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910