DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF585A

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001275729.1	Gene:	ZNF585A / 199704	HGNCID:	26305	Length:	769	Species:	Homo sapiens

Alignment Length:	215	Identity:	81/215 - (37%)
Similarity:	122/215 - (56%)	Gaps:	0/215 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKT 190
            :||.||.|.:.:|...:.|.:.|...:.:.|..|.|.|..:.....|.:.|...||||||.|.|:
Human   550 YECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKS 614

  Fly   191 FAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDN 255
            |..:|.|..|:..||||:|:.|::|.|.|...|:|.:|.:||..|:|:.||:|.|||.:|..|..
Human   615 FTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIT 679

  Fly   256 HFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAER 320
            |.|.||||:|::||.|.|:|..|..|:.|.|:|..::|:.|:.|.|.|...|.|.:|:..|..::
Human   680 HHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDK 744

  Fly   321 TFKCPHCASFYKQRKTLARH 340
            .:||..|...:.|:...:.|
Human   745 PYKCGICGKGFVQKSVFSVH 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071
		C2H2 Zn finger	128..148	CDD:275368	6/19 (32%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		COG5048	<180..341	CDD:227381	67/161 (42%)
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	197..219	CDD:290200	10/21 (48%)
		C2H2 Zn finger	212..232	CDD:275368	7/19 (37%)
		zf-H2C2_2	224..249	CDD:290200	12/24 (50%)
		C2H2 Zn finger	240..260	CDD:275368	10/19 (53%)
		zf-H2C2_2	252..276	CDD:290200	12/23 (52%)
		C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..341	CDD:275368	4/17 (24%)
ZNF585A	NP_001275729.1	C2H2 Zn finger	748..768	CDD:275368	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		COG5048	184..529	CDD:227381
		C2H2 Zn finger	188..208	CDD:275368
		zf-H2C2_2	200..225	CDD:290200
		C2H2 Zn finger	216..236	CDD:275368
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		zf-H2C2_2	284..309	CDD:290200
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..347	CDD:275370
		C2H2 Zn finger	356..376	CDD:275368
		zf-H2C2_2	368..393	CDD:290200
		C2H2 Zn finger	384..404	CDD:275368
		C2H2 Zn finger	412..432	CDD:275368
		C2H2 Zn finger	440..460	CDD:275368
		zf-H2C2_2	455..477	CDD:290200
		C2H2 Zn finger	468..488	CDD:275368
		COG5048	476..768	CDD:227381	81/215 (38%)
		C2H2 Zn finger	496..516	CDD:275368
		zf-H2C2_2	508..533	CDD:290200
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	536..561	CDD:290200	5/10 (50%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		C2H2 Zn finger	580..600	CDD:275368	5/19 (26%)
		zf-H2C2_2	592..617	CDD:290200	11/24 (46%)
		C2H2 Zn finger	608..628	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		zf-H2C2_2	648..673	CDD:290200	12/24 (50%)
		C2H2 Zn finger	664..684	CDD:275368	10/19 (53%)
		zf-H2C2_2	676..700	CDD:290200	12/23 (52%)
		C2H2 Zn finger	692..712	CDD:275368	9/19 (47%)
		zf-H2C2_2	705..728	CDD:290200	8/22 (36%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)
		zf-H2C2_2	732..757	CDD:290200	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910