DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF483

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_597721.2	Gene:	ZNF483 / 158399	HGNCID:	23384	Length:	744	Species:	Homo sapiens

Alignment Length:	368	Identity:	108/368 - (29%)
Similarity:	183/368 - (49%)	Gaps:	54/368 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GKLVN----IFDARRRTRVSIAEMIAQCTGFEVKRGDLF---------SEMICPQCYEDVKSAYG 64
            ||:::    :.:.::|.::.:.:...:|:    |.|.:|         ...:|.:|.:|
Human   365 GKVLSHSSALTEHQKRQKIHLGDRSQKCS----KCGIIFIRRSTLSRRKTPMCEKCRKD------ 419

  Fly    65 IRQTCEESHQFYCRVRDEGIED-------ALC--------ALLE-------EEDWEISEDEDARI 107
               :|:|:    ...:|||.|.       :.|        :|.:       |:.:..:|...|..
Human   420 ---SCQEA----ALNKDEGNESGEKTHKCSKCGKAFGYSASLTKHRRIHTGEKPYMCNECGKAFS 477

  Fly   108 DSASAADDDGKSDSKKVAFECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAH 172
            ||:|..... ::.|.:..|:|.:|.|.:......::|.|.|...:.:.|..|.|.|....:|..|
Human   478 DSSSLTPHH-RTHSGEKPFKCDDCGKGFTLSAHLIKHQRIHTGEKPYKCKDCGRPFSDSSSLIQH 541

  Fly   173 MKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERP 237
            .:.|...|||.||:|.|:|:..|:|..|:|.||||:|:||.:|.|.|.::|.|.||.|.|..|:|
Human   542 QRIHTGEKPYTCSNCGKSFSHSSSLSKHQRIHTGEKPYKCGECGKAFRQNSCLTRHQRIHTGEKP 606

  Fly   238 FKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKT 302
            :.|:.|..||:....:..|.|.|:||:|:||:.|.|||.....|.:|.|:|...:|::|..|.|:
Human   607 YLCNDCGMTFSHFTSVIYHQRLHSGEKPYKCNQCEKAFPTHSLLSRHQRIHTGVKPYKCKECGKS 671

  Fly   303 FRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARHILEIH 345
            |..||:|.||..:|..|:.::|.:|.:.:.:...|..| |:||
Human   672 FSQSSSLNEHHRIHTGEKPYECNYCGATFSRSSILVEH-LKIH 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	12/77 (16%)
		C2H2 Zn finger	128..148	CDD:275368	5/19 (26%)
		C2H2 Zn finger	156..176	CDD:275368	6/19 (32%)
		COG5048	<180..341	CDD:227381	65/160 (41%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..219	CDD:290200	12/21 (57%)
		C2H2 Zn finger	212..232	CDD:275368	9/19 (47%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		zf-H2C2_2	252..276	CDD:290200	11/23 (48%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..341	CDD:275368	3/16 (19%)
ZNF483	NP_597721.2	SCAN	49..152	CDD:128708
		SCAN	49..136	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..156
		KRAB	171..229	CDD:214630
		KRAB	171..209	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..385		3/19 (16%)
		C2H2 Zn finger	361..384	CDD:275368	3/18 (17%)
		C2H2 Zn finger	413..433	CDD:275368	8/32 (25%)
		COG5048	437..>735	CDD:227381	92/279 (33%)
		C2H2 Zn finger	441..461	CDD:275368	2/19 (11%)
		zf-H2C2_2	453..477	CDD:290200	4/23 (17%)
		C2H2 Zn finger	469..489	CDD:275368	5/20 (25%)
		zf-H2C2_2	485..505	CDD:290200	5/20 (25%)
		C2H2 Zn finger	497..517	CDD:275368	5/19 (26%)
		zf-H2C2_2	509..533	CDD:290200	6/23 (26%)
		zf-C2H2	523..545	CDD:278523	6/21 (29%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		zf-C2H2	579..601	CDD:278523	10/21 (48%)
		C2H2 Zn finger	581..601	CDD:275368	9/19 (47%)
		zf-H2C2_2	594..618	CDD:290200	11/23 (48%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		zf-H2C2_2	625..644	CDD:290200	10/18 (56%)
		C2H2 Zn finger	637..657	CDD:275368	8/19 (42%)
		zf-H2C2_2	650..674	CDD:290200	9/23 (39%)
		C2H2 Zn finger	665..685	CDD:275368	9/19 (47%)
		zf-H2C2_2	677..702	CDD:290200	7/24 (29%)
		C2H2 Zn finger	693..713	CDD:275368	5/20 (25%)
		zf-H2C2_2	706..730	CDD:290200	5/9 (56%)
		C2H2 Zn finger	721..741	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910