DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF354B

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_478137.1	Gene:	ZNF354B / 117608	HGNCID:	17197	Length:	612	Species:	Homo sapiens

Alignment Length:	220	Identity:	88/220 - (40%)
Similarity:	124/220 - (56%)	Gaps:	1/220 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKT 190
            |:|.||.:.:.:..:.::|.|.|...:.:.|..|.:.|.....|..|...|...|.|.|:.|.|.
Human   382 FKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKLYNCNECGKA 446

  Fly   191 FAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDN 255
            .:..|||..|||.||||:|.||..|.|.|.:||.|.:|.|.|..|||:||::|.|||.....|.|
Human   447 LSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECDKTFRCNSSLSN 511

  Fly   256 HFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAER 320
            |.|.||||:|::|..|..:|.....|.||.|:|..::||:|:.|.||||.||:|..|:.:|..|:
Human   512 HQRIHTGEKPYRCLECGMSFGQSAALIQHQRIHTGEKPFKCNTCGKTFRQSSSLIAHQRIHTGEK 576

  Fly   321 TFKCPHCASFYKQRKTLARHILEIH 345
            .::|..|...:.||.:|..| .:||
Human   577 PYECNACGKLFSQRSSLTNH-YKIH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071
		C2H2 Zn finger	128..148	CDD:275368	5/19 (26%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		COG5048	<180..341	CDD:227381	72/160 (45%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..219	CDD:290200	13/21 (62%)
		C2H2 Zn finger	212..232	CDD:275368	9/19 (47%)
		zf-H2C2_2	224..249	CDD:290200	13/24 (54%)
		C2H2 Zn finger	240..260	CDD:275368	9/19 (47%)
		zf-H2C2_2	252..276	CDD:290200	11/23 (48%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	10/19 (53%)
		C2H2 Zn finger	324..341	CDD:275368	5/16 (31%)
ZNF354B	NP_478137.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..102
		COG5048	184..596	CDD:227381	85/213 (40%)
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368
		zf-H2C2_2	228..253	CDD:290200
		C2H2 Zn finger	244..264	CDD:275368
		zf-H2C2_2	256..281	CDD:290200
		C2H2 Zn finger	272..292	CDD:275368
		zf-C2H2	298..320	CDD:278523
		C2H2 Zn finger	300..320	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..340
		C2H2 Zn finger	356..376	CDD:275368
		zf-H2C2_2	368..393	CDD:290200	4/10 (40%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		zf-H2C2_2	396..421	CDD:290200	6/24 (25%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		zf-H2C2_2	453..477	CDD:290200	14/23 (61%)
		C2H2 Zn finger	468..488	CDD:275368	9/19 (47%)
		zf-H2C2_2	480..505	CDD:290200	13/24 (54%)
		C2H2 Zn finger	496..516	CDD:275368	9/19 (47%)
		zf-H2C2_2	508..531	CDD:290200	11/22 (50%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..572	CDD:275368	10/19 (53%)
		zf-H2C2_2	564..589	CDD:290200	6/24 (25%)
		C2H2 Zn finger	580..600	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910