DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF268

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	215	Identity:	86/215 - (40%)
Similarity:	119/215 - (55%)	Gaps:	0/215 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKT 190
            :||.||.|.:.||...:.|.|||...:.:.|..|.:.|.|:..|..|.:||...||:|||.|.|.
Human   556 YECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQKA 620

  Fly   191 FAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDN 255
            |..:|.|..|:||||||:|:.|::|.|.|...|.|..|...|...:|:.||:|.|||:.|..|..
Human   621 FNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQLIV 685

  Fly   256 HFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAER 320
            |.|||||.:|:.||.|.|||..|.:|..|.|.|..::|..|..|.|:|..:|.|..|:.:|..|.
Human   686 HQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTGEKPHECRECGKSFSFNSQLIVHQRIHTGEN 750

  Fly   321 TFKCPHCASFYKQRKTLARH 340
            .::|..|...:.::..|..|
Human   751 PYECSECGKAFNRKDQLISH 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071
		C2H2 Zn finger	128..148	CDD:275368	8/19 (42%)
		C2H2 Zn finger	156..176	CDD:275368	6/19 (32%)
		COG5048	<180..341	CDD:227381	67/161 (42%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..219	CDD:290200	12/21 (57%)
		C2H2 Zn finger	212..232	CDD:275368	7/19 (37%)
		zf-H2C2_2	224..249	CDD:290200	10/24 (42%)
		C2H2 Zn finger	240..260	CDD:275368	10/19 (53%)
		zf-H2C2_2	252..276	CDD:290200	13/23 (57%)
		C2H2 Zn finger	268..288	CDD:275368	10/19 (53%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..341	CDD:275368	4/17 (24%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368
		zf-H2C2_2	347..371	CDD:290200
		C2H2 Zn finger	362..382	CDD:275368
		zf-H2C2_2	375..397	CDD:290200
		C2H2 Zn finger	390..410	CDD:275368
		zf-H2C2_2	403..427	CDD:290200
		C2H2 Zn finger	418..438	CDD:275368
		zf-H2C2_2	430..454	CDD:290200
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..494	CDD:275368
		COG5048	497..910	CDD:227381	86/215 (40%)
		C2H2 Zn finger	502..522	CDD:275368
		C2H2 Zn finger	530..550	CDD:275368
		zf-H2C2_2	543..567	CDD:290200	5/10 (50%)
		zf-C2H2	556..578	CDD:278523	9/21 (43%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
		C2H2 Zn finger	586..606	CDD:275368	6/19 (32%)
		zf-H2C2_2	599..623	CDD:290200	12/23 (52%)
		C2H2 Zn finger	614..634	CDD:275368	9/19 (47%)
		zf-H2C2_2	626..650	CDD:290200	12/23 (52%)
		C2H2 Zn finger	642..662	CDD:275368	7/19 (37%)
		C2H2 Zn finger	670..690	CDD:275368	10/19 (53%)
		C2H2 Zn finger	698..718	CDD:275368	10/19 (53%)
		zf-H2C2_2	710..734	CDD:290200	8/23 (35%)
		C2H2 Zn finger	726..746	CDD:275368	7/19 (37%)
		zf-H2C2_2	739..763	CDD:290200	6/23 (26%)
		C2H2 Zn finger	754..774	CDD:275368	4/17 (24%)
		C2H2 Zn finger	782..802	CDD:275368
		zf-H2C2_2	794..817	CDD:290200
		C2H2 Zn finger	810..830	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		zf-H2C2_2	851..875	CDD:290200
		C2H2 Zn finger	866..886	CDD:275368
		C2H2 Zn finger	894..914	CDD:275368
		zf-H2C2_2	907..929	CDD:290200
		C2H2 Zn finger	922..942	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910