DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15436 and ZNF460

DIOPT Version :9

Sequence 1:NP_608840.1 Gene:CG15436 / 33657 FlyBaseID:FBgn0031610 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_006626.3 Gene:ZNF460 / 10794 HGNCID:21628 Length:562 Species:Homo sapiens


Alignment Length:381 Identity:118/381 - (30%)
Similarity:180/381 - (47%) Gaps:49/381 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VCMDISGKLVNIFDARR-------------RTRVSIAEMIAQCTGFEVKRGDLFSEMICPQCYED 58
            |.::..|.||.:.|:.:             ...||:.|.:||    .|.|.....:.:......:
Human    41 VMLETCGLLVALGDSTKPETVEPIPSHLALPEEVSLQEQLAQ----GVPRYSYLGQAMDQDGPSE 101

  Fly    59 VKSAYGIRQTCEESHQFYCR--VRDEGI--EDALCALLEEEDWEIS-EDEDARIDSASAADD--- 115
            ::..:....|..:|.:.:.:  :..||:  .|.:|:::.:.  ::| ||.....||.....|   
Human   102 MQEYFLRPGTDPQSEKLHGKMSLEHEGLATADGICSMMIQN--QVSPEDALYGFDSYGPVTDSLI 164

  Fly   116 -DGKSDSK-------------------KV-AFECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYC 159
             :|::..|                   :| .::|.||.|.:.:....|:|...|...:.:.|..|
Human   165 HEGENSYKFEEMFNENCFLVQHEQILPRVKPYDCPECGKAFGKSKHLLQHHIIHTGEKPYKCLEC 229

  Fly   160 KRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSD 224
            .::|..|..|..|.:|||..||:.||.|.:||.:.|.|..|:|.|:||:||.|::|.|.|...|:
Human   230 GKDFNRRSHLTRHQRTHNGDKPFVCSECGRTFNRGSHLTRHQRVHSGEKPFVCNECGKAFTYRSN 294

  Fly   225 LRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHL 289
            ...|.::|..::||.||:|.|.|.....|..||..|||||||||..|.|||..:.|||||.|:|.
Human   295 FVLHNKSHNEKKPFACSECGKGFYESTALIQHFIIHTGERPFKCLECGKAFNCRSHLKQHERIHT 359

  Fly   290 PDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARHILEIH 345
            .::||.||.|.|.|...||...|:..|..|:.|:|..|...:..||.|.|| ..||
Human   360 GEKPFVCSQCGKAFTHYSTYVLHERAHTGEKPFECKECGKAFSIRKDLIRH-FNIH 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15436NP_608840.1 zf-AD 4..78 CDD:285071 14/83 (17%)
C2H2 Zn finger 128..148 CDD:275368 6/19 (32%)
C2H2 Zn finger 156..176 CDD:275368 6/19 (32%)
COG5048 <180..341 CDD:227381 72/160 (45%)
C2H2 Zn finger 184..204 CDD:275368 9/19 (47%)
zf-H2C2_2 197..219 CDD:290200 11/21 (52%)
C2H2 Zn finger 212..232 CDD:275368 6/19 (32%)
zf-H2C2_2 224..249 CDD:290200 9/24 (38%)
C2H2 Zn finger 240..260 CDD:275368 8/19 (42%)
zf-H2C2_2 252..276 CDD:290200 15/23 (65%)
C2H2 Zn finger 268..288 CDD:275368 11/19 (58%)
C2H2 Zn finger 296..316 CDD:275368 8/19 (42%)
C2H2 Zn finger 324..341 CDD:275368 6/16 (38%)
ZNF460NP_006626.3 KRAB 12..53 CDD:307490 4/11 (36%)
C2H2 Zn finger 198..218 CDD:275368 6/19 (32%)
COG5048 222..552 CDD:227381 84/194 (43%)
C2H2 Zn finger 226..246 CDD:275368 6/19 (32%)
C2H2 Zn finger 254..274 CDD:275368 9/19 (47%)
C2H2 Zn finger 282..302 CDD:275368 6/19 (32%)
C2H2 Zn finger 310..330 CDD:275368 8/19 (42%)
C2H2 Zn finger 338..358 CDD:275368 11/19 (58%)
C2H2 Zn finger 366..386 CDD:275368 8/19 (42%)
C2H2 Zn finger 394..414 CDD:275368 7/20 (35%)
C2H2 Zn finger 422..442 CDD:275368
C2H2 Zn finger 450..470 CDD:275368
C2H2 Zn finger 478..498 CDD:275368
C2H2 Zn finger 506..526 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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